You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PRLR
Prolactin receptor

Protein Summary
Description
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231423
  • ENSP00000231423
  • ENSG00000113494
  • ENST00000310101
  • ENSP00000309008
  • ENST00000348262
  • ENSP00000311613
  • ENST00000509140
  • ENSP00000425300
  • ENST00000511486
  • ENSP00000422556
  • ENST00000513753
  • ENSP00000424841
  • ENST00000514088
  • ENSP00000422935
  • ENST00000542609
  • ENSP00000441813
  • ENST00000618457
  • ENSP00000482954
  • ENST00000619676
  • ENSP00000484768
  • ENST00000620785
  • ENSP00000482689

Symbol
  • HPRL
  • MFAB
  • hPRLrI
  • RI-PRLR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.94
biological process
0.9
trait
0.86
gene perturbation
0.85
ligand (protein)
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660.52   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 838   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660.52   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 838   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
2
3
92.6
psychotic symptoms
1
1
0
1.6
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
92.6
psychotic symptoms
0
1.6
4.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
prolactin receptor
699369
Mouse
MGI:97763
19116
Rat
RGD:3407
24684
Dog
prolactin receptor
VGNC:44994
479363
Horse
prolactin receptor
VGNC:21857
100053793
Species
Name
OMA
EggNOG
Inparanoid
Macaque
prolactin receptor
Mouse
Rat
Dog
prolactin receptor
Horse
prolactin receptor
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P16471-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (144)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Growth hormone receptor signaling
Reactome
Immune System
Reactome
Prolactin receptor signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Growth hormone receptor signaling
Immune System
Prolactin receptor signaling
Gene Ontology Terms (24)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (140)
1 – 10 of 140
PRL
Tbio
Novelty: 0.0000905
Score: 0.999
Data Source: Reactome,STRINGDB
GH1
Tbio
Novelty: 0.00072523
Score: 0.992
Data Source: Reactome,STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00074178
Score: 0.988
Data Source: Reactome,STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.987
Data Source: Reactome,STRINGDB
CSH1
Tbio
Novelty: 0.00100314
Score: 0.981
Data Source: Reactome,STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.981
Data Source: Reactome,STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.948
Data Source: Reactome,STRINGDB
GH2
Tbio
Novelty: 0.00071871
Score: 0.946
Data Source: Reactome,STRINGDB
BTRC
Tbio
Novelty: 0.00293475
Score: 0.942
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.942
Data Source: STRINGDB
Publication Statistics
PubMed Score  660.52

PubMed score by year
PubTator Score  415.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: