Pharos : Target Details

Tbio

Protein Classes

Protein Summary

Description

This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

Gene Name

PRLR

Ensembl ID

ENST00000231423
ENSP00000231423
ENSG00000113494
ENST00000310101
ENSP00000309008
ENST00000348262
ENSP00000311613
ENST00000509140
ENSP00000425300
ENST00000511486
ENSP00000422556
ENST00000513753
ENSP00000424841
ENST00000514088
ENSP00000422935
ENST00000542609
ENSP00000441813
ENST00000618457
ENSP00000482954
ENST00000619676
ENSP00000484768
ENST00000620785
ENSP00000482689

Symbol

HPRL
MFAB
hPRLrI
RI-PRLR

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.94

biological process	0.9

trait	0.86

gene perturbation	0.85

ligand (protein)	0.85

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660.52 (req: < 5)

View Publications

Gene RIFs: 103 (req: <= 3)

View Gene RIFs

Antibodies: 838 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660.52 (req: >= 5)

Gene RIFs: 103 (req: > 3)

Antibodies: 838 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
testosterone measurement	EFO_0004908	3	2	3		92.6

psychotic symptoms	EFO_0005940	1	1	0	1.6	4.7

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
testosterone measurement	EFO_0004908	3		92.6

psychotic symptoms	EFO_0005940	0	1.6	4.7

Beta Count

Odds Ratio

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID
Macaque	prolactin receptor		699369

Mouse	prolactin receptor	MGI:97763	19116

Rat	prolactin receptor	RGD:3407	24684

Dog	prolactin receptor	VGNC:44994	479363

Horse	prolactin receptor	VGNC:21857	100053793

Species	Name	OMA	EggNOG	Inparanoid
Macaque	prolactin receptor

Mouse	prolactin receptor

Rat	prolactin receptor

Dog	prolactin receptor

Horse	prolactin receptor

Protein Data Bank (12)

1 – 5 of 12

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (144)

Reactome (4)

KEGG (5)

PathwayCommons (6)

WikiPathways (129)

Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Reactome	Growth hormone receptor signaling	24 targets	R-HSA-982772

Reactome	Immune System	2246 targets	R-HSA-168256

Reactome	Prolactin receptor signaling	15 targets	R-HSA-1170546

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Growth hormone receptor signaling	24 targets	R-HSA-982772

Immune System	2246 targets	R-HSA-168256

Prolactin receptor signaling	15 targets	R-HSA-1170546

Gene Ontology Terms (24)

Functions (7)

Components (7)

Processes (10)

Items per page:

1 – 7 of 7

GO Term	Evidence	Assigned by
peptide hormone binding	Inferred from Physical Interaction (IPI)	BHF-UCL

cytokine binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

cytokine receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

prolactin receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

ornithine decarboxylase activator activity	Non-traceable Author Statement (NAS)	UniProtKB

protein homodimerization activity	Non-traceable Author Statement (NAS)	UniProtKB

metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (140)

1 – 10 of 140

See Interactions on String-DB

PRL

Tbio

Novelty: 0.0000905

Score: 0.999