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Tbio
PRLR
Prolactin receptor

Protein Summary
Description
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231423
  • ENSP00000231423
  • ENSG00000113494
  • ENST00000310101
  • ENSP00000309008
  • ENST00000348262
  • ENSP00000311613
  • ENST00000509140
  • ENSP00000425300
  • ENST00000511486
  • ENSP00000422556
  • ENST00000513753
  • ENSP00000424841
  • ENST00000514088
  • ENSP00000422935
  • ENST00000542609
  • ENSP00000441813
  • ENST00000618457
  • ENSP00000482954
  • ENST00000619676
  • ENSP00000484768
  • ENST00000620785
  • ENSP00000482689

Symbol
  • HPRL
  • MFAB
  • hPRLrI
  • RI-PRLR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.94
biological process
0.9
trait
0.86
gene perturbation
0.85
ligand (protein)
0.85


IDG Partner Tools
GlyGen
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660.52   (req: < 5)
View Publications
Gene RIFs: 103   (req: <= 3)
View Gene RIFs
Antibodies: 838   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660.52   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 838   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
EFO_0004908
3
2
3
92.6
psychotic symptoms
EFO_0005940
1
1
0
1.6
4.7
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
EFO_0004908
3
92.6
psychotic symptoms
EFO_0005940
0
1.6
4.7
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (144)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
922 targets
R-HSA-1280215
Reactome
Growth hormone receptor signaling
24 targets
R-HSA-982772
Reactome
Immune System
2246 targets
R-HSA-168256
Reactome
Prolactin receptor signaling
15 targets
R-HSA-1170546
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
922 targets
R-HSA-1280215
Growth hormone receptor signaling
24 targets
R-HSA-982772
Immune System
2246 targets
R-HSA-168256
Prolactin receptor signaling
15 targets
R-HSA-1170546
Gene Ontology Terms (24)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
peptide hormone binding
Inferred from Physical Interaction (IPI)
BHF-UCL
cytokine binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
cytokine receptor activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
prolactin receptor activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
ornithine decarboxylase activator activity
Non-traceable Author Statement (NAS)
UniProtKB
protein homodimerization activity
Non-traceable Author Statement (NAS)
UniProtKB
metal ion binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (140)
1 – 10 of 140
PRL
Tbio
Novelty: 0.0000905
Score: 0.999
Data Source: Reactome,STRINGDB
GH1
Tbio
Novelty: 0.00072523
Score: 0.992
Data Source: Reactome,STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00074178
Score: 0.988
Data Source: Reactome,STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.987
Data Source: Reactome,STRINGDB
CSH1
Tbio
Novelty: 0.00100314
Score: 0.981
Data Source: Reactome,STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.981
Data Source: Reactome,STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.948
Data Source: Reactome,STRINGDB
GH2
Tbio
Novelty: 0.00071871
Score: 0.946
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.942
Data Source: STRINGDB
BTRC
Tbio
Novelty: 0.00293475
Score: 0.942
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  660.52

PubMed score by year
PubTator Score  415.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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