Protein Summary
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
- ENST00000231423
- ENSP00000231423
- ENSG00000113494
- ENST00000310101
- ENSP00000309008
- ENST00000348262
- ENSP00000311613
- ENST00000509140
- ENSP00000425300
- ENST00000511486
- ENSP00000422556
- ENST00000513753
- ENSP00000424841
- ENST00000514088
- ENSP00000422935
- ENST00000542609
- ENSP00000441813
- ENST00000618457
- ENSP00000482954
- ENST00000619676
- ENSP00000484768
- ENST00000620785
- ENSP00000482689
- HPRL
- MFAB
- hPRLrI
- RI-PRLR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.94 | ||
biological process | 0.9 | ||
trait | 0.86 | ||
gene perturbation | 0.85 | ||
ligand (protein) | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 669.74 (req: < 5)
Gene RIFs: 103 (req: <= 3)
Antibodies: 838 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 669.74 (req: >= 5)
Gene RIFs: 103 (req: > 3)
Antibodies: 838 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (140)
Nearest Tclin Targets (32)
Upstream (18)
Downstream (14)
1 – 5 of 18
Pathways (144)
Reactome (4)
KEGG (5)
PathwayCommons (6)
WikiPathways (129)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Growth hormone receptor signaling | ||||
Reactome | Immune System | ||||
Reactome | Prolactin receptor signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Growth hormone receptor signaling | ||||
Immune System | ||||
Prolactin receptor signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (7)
Components (7)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urinary metabolite measurement | 2 | 4 | 11 | 98.2 | |||||
symmetrical dimethylarginine measurement | 1 | 1 | 1 | 81.5 | |||||
3-hydroxyisobutyrate measurement | 1 | 1 | 1 | 76.3 | |||||
3-aminoisobutyrate measurement | 1 | 1 | 1 | 76.3 | |||||
testosterone measurement | 3 | 2 | 3 | 72.2 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urinary metabolite measurement | 11 | 98.2 | |||||
symmetrical dimethylarginine measurement | 1 | 81.5 | |||||
3-hydroxyisobutyrate measurement | 1 | 76.3 | |||||
3-aminoisobutyrate measurement | 1 | 76.3 | |||||
testosterone measurement | 3 | 72.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | prolactin receptor | 699369 | ||||||
Mouse | MGI:97763 | 19116 | ||||||
Rat | RGD:3407 | 24684 | ||||||
Dog | prolactin receptor | VGNC:44994 | 479363 | |||||
Horse | prolactin receptor | VGNC:21857 | 100053793 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | prolactin receptor | |||||
Mouse | ||||||
Rat | ||||||
Dog | prolactin receptor | |||||
Horse | prolactin receptor | |||||
Publication Statistics
PubMed Score 669.74
PubMed score by year
PubTator Score 415.70
PubTator score by year
Related Publications
Text Mined References (152)
GeneRif Annotations (103)
Items per page:
0 of 0
PMID | Year | Title |
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