Tbio PRLR Prolactin receptor

Protein Summary

Description

This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• P16471
• B2R882
• D1MDP1
• Q16354
• Q8TD75
• Q8TD78
• Q96P35
• Q96P36
• Q9BX87
• Q9UHJ5
• PRL-R

Gene Name

• PRLR

Ensembl ID

• ENST00000231423
• ENSP00000231423
• ENSG00000113494
• ENST00000310101
• ENSP00000309008
• ENST00000348262
• ENSP00000311613
• ENST00000509140
• ENSP00000425300
• ENST00000511486
• ENSP00000422556
• ENST00000513753
• ENSP00000424841
• ENST00000514088
• ENSP00000422935
• ENST00000542609
• ENSP00000441813
• ENST00000618457
• ENSP00000482954
• ENST00000619676
• ENSP00000484768
• ENST00000620785
• ENSP00000482689

Symbol

• HPRL
• MFAB
• hPRLrI
• RI-PRLR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.94
biological process	0.9
trait	0.86
gene perturbation	0.85
ligand (protein)	0.85

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Prolactin Receptor

Protein / Defense/immunity Protein / Prolactin Receptor

DTO Classes

Protein / Signaling / Cytokine / Prolactin Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 698.51   (req: < 5)

Gene RIFs: 118   (req: <= 3)

Antibodies: 838   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 698.51   (req: >= 5)

Gene RIFs: 118   (req: > 3)

Antibodies: 838   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0