Pharos : Target Details

Tbio

Protein Classes

Protein Summary

Description

This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

Gene Name

PRLR

Ensembl ID

ENST00000231423
ENSP00000231423
ENSG00000113494
ENST00000310101
ENSP00000309008
ENST00000348262
ENSP00000311613
ENST00000509140
ENSP00000425300
ENST00000511486
ENSP00000422556
ENST00000513753
ENSP00000424841
ENST00000514088
ENSP00000422935
ENST00000542609
ENSP00000441813
ENST00000618457
ENSP00000482954
ENST00000619676
ENSP00000484768
ENST00000620785
ENSP00000482689

Symbol

HPRL
MFAB
hPRLrI
RI-PRLR

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.94

biological process	0.9

trait	0.86

gene perturbation	0.85

ligand (protein)	0.85

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 638.69 (req: < 5)

View Publications

Gene RIFs: 103 (req: <= 3)

View Gene RIFs

Antibodies: 838 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 638.69 (req: >= 5)

Gene RIFs: 103 (req: > 3)

Antibodies: 838 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (12)

1 – 5 of 12

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (144)

Reactome (4)

KEGG (5)

PathwayCommons (6)

WikiPathways (129)

Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Reactome	Growth hormone receptor signaling	24 targets	R-HSA-982772

Reactome	Immune System	2246 targets	R-HSA-168256

Reactome	Prolactin receptor signaling	15 targets	R-HSA-1170546

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Growth hormone receptor signaling	24 targets	R-HSA-982772

Immune System	2246 targets	R-HSA-168256

Prolactin receptor signaling	15 targets	R-HSA-1170546

Gene Ontology Terms (24)

Functions (7)

Components (7)

Processes (10)

Items per page:

1 – 7 of 7

GO Term	Evidence	Assigned by
peptide hormone binding	Inferred from Physical Interaction (IPI)	BHF-UCL

cytokine binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

cytokine receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

prolactin receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

ornithine decarboxylase activator activity	Non-traceable Author Statement (NAS)	UniProtKB

protein homodimerization activity	Non-traceable Author Statement (NAS)	UniProtKB

metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (140)

1 – 10 of 140

See Interactions on String-DB

PRL

Tbio

Novelty: 0.00010121

Score: 0.999

Data Source: Reactome,STRINGDB

GH1

Tbio

Novelty: 0.00082468

Score: 0.992

Data Source: Reactome,STRINGDB

STAT5B

Tchem

Family: TF

Novelty: 0.00091216

Score: 0.988

Data Source: Reactome,STRINGDB

STAT5A

Tchem

Family: TF

Novelty: 0.00091229

Score: 0.987

Data Source: Reactome,STRINGDB

CSH1

Tbio

Novelty: 0.00110788

Score: 0.981

Data Source: Reactome,STRINGDB

JAK2

Tclin

Family: Kinase

Novelty: 0.00028252

Score: 0.981

Data Source: Reactome,STRINGDB

PTPN11

Tchem

Family: Enzyme

Novelty: 0.00086268

Score: 0.948

Data Source: Reactome,STRINGDB

GH2

Tbio

Novelty: 0.00081585

Score: 0.946

Data Source: Reactome,STRINGDB

STAT3

Tchem

Family: TF

Novelty: 0.00013496

Score: 0.942

Data Source: STRINGDB

BTRC

Tbio

Novelty: 0.00393331

Score: 0.942

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score 638.69

PubMed score by year

PubTator Score 415.7

PubTator score by year

Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure

Alternative splicing

Complete proteome

Disease mutation

Disulfide bond

Glycoprotein

Membrane

Metal-binding

Polymorphism

Receptor

GWAS Trait

MGI Phenotype


adipose tissue phenotype

behavior/neurological phenotype

cellular phenotype

embryo phenotype

endocrine/exocrine gland phenotype

growth/size/body region phenotype

homeostasis/metabolism phenotype

integument phenotype

neoplasm

nervous system phenotype


age-related macular degeneration

atrophic macular degeneration

chronic kidney disease

psychotic symptoms

symmetrical dimethylarginine measurement

urinary metabolite measurement

wet macular degeneration