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Tchem
MGMT
Methylated-DNA--protein-cysteine methyltransferase

Protein Summary
Description
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306010
  • ENSP00000302111
  • ENSG00000170430
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
chemical
0.89
histone modification site profile
0.87
disease
0.86
biological process
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2261.08   (req: < 5)
Gene RIFs: 541   (req: <= 3)
Antibodies: 758   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2261.08   (req: >= 5)
Gene RIFs: 541   (req: > 3)
Antibodies: 758   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 34
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
86.3
1
1
0
1.1
49.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
86.3
0
1.1
49.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
O-6-methylguanine-DNA methyltransferase
VGNC:7280
737624
Macaque
O-6-methylguanine-DNA methyltransferase
698134
Mouse
MGI:96977
17314
Rat
RGD:3087
25332
Dog
O-6-methylguanine-DNA methyltransferase
VGNC:43213
442978
Species
Name
OMA
EggNOG
Inparanoid
Chimp
O-6-methylguanine-DNA methyltransferase
Macaque
O-6-methylguanine-DNA methyltransferase
Mouse
Rat
Dog
O-6-methylguanine-DNA methyltransferase
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P16455-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
DNA Damage Reversal (R-HSA-73942)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Reversal
Reactome
DNA Repair
Reactome
MGMT-mediated DNA damage reversal
Name
Explore in Pharos
Explore in Source
DNA Damage Reversal
DNA Repair
MGMT-mediated DNA damage reversal
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (183)
1 – 10 of 183
MLH1
Tbio
Novelty: 0.00034212
Score: 0.908
Data Source: STRINGDB
RASSF1
Tbio
Novelty: 0.00137149
Score: 0.899
Data Source: STRINGDB
IDH1
Tclin
Family: Enzyme
Novelty: 0.0004831
Score: 0.898
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.895
Data Source: STRINGDB
MSH6
Tbio
Family: Epigenetic
Novelty: 0.00097439
Score: 0.844
Data Source: STRINGDB
LIG4
Tbio
Family: Enzyme
Novelty: 0.00412993
Score: 0.84
Data Source: STRINGDB
TRIP12
Tbio
Family: Enzyme
Novelty: 0.03433452
Score: 0.831
Data Source: STRINGDB
OGG1
Tbio
Family: Enzyme
Novelty: 0.00074509
Score: 0.81
Data Source: STRINGDB
CDH13
Tbio
Novelty: 0.00389516
Score: 0.802
Data Source: STRINGDB
IDH2
Tclin
Family: Enzyme
Novelty: 0.00131782
Score: 0.8
Data Source: STRINGDB
Publication Statistics
PubMed Score  2261.08

PubMed score by year
PubTator Score  2260.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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