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Tbio
EPB42
Erythrocyte membrane protein band 4.2

Protein Summary
Description
Probably plays an important role in the regulation of erythrocyte shape and mechanical properties. Erythrocyte membrane protein band 4.2 is an ATP-binding protein which may regulate the association of protein 3 with ankyrin. It probably has a role in erythrocyte shape and mechanical property regulation. Mutations in the EPB42 gene are associated with recessive spherocytic elliptocytosis and recessively transmitted hereditary hemolytic anemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000441366
  • ENSP00000396616
  • ENSG00000166947
  • ENST00000568508
  • ENSP00000457140
  • ENST00000622454
  • ENSP00000481226
  • ENST00000648595
  • ENSP00000497777

Symbol
  • E42P
  • PA
  • SPH5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.91
gene perturbation
0.78
co-expressed gene
0.52
tissue
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.63   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.63   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
SLC4A7
Tbio
Family:  Transporter
Novelty:  0.011156
p_int:  0.995007874
p_ni:  0.004992123
p_wrong:  4e-9
Score:  0.298
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.887349903
p_ni:  0.112650097
Data Source:  BioPlex
SNX6
Tbio
Novelty:  0.05909848
p_int:  0.78327321
p_ni:  0.208628628
p_wrong:  0.008098162
Score:  0.248
Data Source:  BioPlex,STRINGDB
SLC4A1
Tbio
Family:  Transporter
Novelty:  0.00290106
Score:  0.939
Data Source:  STRINGDB
ALAS2
Tbio
Family:  Enzyme
Novelty:  0.00491418
Score:  0.918
Data Source:  STRINGDB
AHSP
Tbio
Novelty:  0.00996928
Score:  0.9
Data Source:  STRINGDB
DMTN
Tbio
Novelty:  0.01330153
Score:  0.876
Data Source:  STRINGDB
SPTA1
Tbio
Novelty:  0.00456741
Score:  0.81
Data Source:  STRINGDB
GYPB
Tbio
Novelty:  0.00442195
Score:  0.786
Data Source:  STRINGDB
KLF1
Tbio
Family:  TF
Novelty:  0.00370238
Score:  0.784
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
59.6
high density lipoprotein cholesterol measurement
1
1
1
53.3
apolipoprotein A 1 measurement
1
1
1
45.2
self reported educational attainment
1
1
1
26.6
household income
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
59.6
high density lipoprotein cholesterol measurement
1
53.3
apolipoprotein A 1 measurement
1
45.2
self reported educational attainment
1
26.6
household income
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
erythrocyte membrane protein band 4.2
709427
Mouse
MGI:95402
13828
Rat
RGD:1305306
362202
Dog
erythrocyte membrane protein band 4.2
VGNC:40399
608932
Horse
erythrocyte membrane protein band 4.2
VGNC:17612
100070868
Species
Name
OMA
EggNOG
Inparanoid
Macaque
erythrocyte membrane protein band 4.2
Mouse
Rat
Dog
erythrocyte membrane protein band 4.2
Horse
erythrocyte membrane protein band 4.2
Publication Statistics
PubMed Score 11.63
PubMed score by year
PubTator Score 137.89
PubTator score by year
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Related Publications
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PMID
Year
Title