Tbio POR NADPH--cytochrome P450 reductase

Protein Summary

Description

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P16435
• Q16455
• Q197M5
• Q8N181
• Q9H3M8
• Q9UDT3
• CPR

Gene Name

• POR

Ensembl ID

• ENST00000394893
• ENSP00000378355
• ENSG00000127948
• ENST00000412064
• ENSP00000404731
• ENST00000412521
• ENSP00000409238
• ENST00000414186
• ENSP00000399327
• ENST00000418341
• ENSP00000389719
• ENST00000432753
• ENSP00000389409
• ENST00000439963
• ENSP00000390540
• ENST00000449920
• ENSP00000399556
• ENST00000453773
• ENSP00000395813
• ENST00000454934
• ENSP00000414263
• ENST00000461988
• ENSP00000419970

Symbol

• CYPOR
• CPR
• CYPOR
• P450R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
biological process	0.98
molecular function	0.98
chemical	0.97
transcription factor binding site profile	0.93

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 676.31   (req: < 5)

Gene RIFs: 127   (req: <= 3)

Antibodies: 388   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 676.31   (req: >= 5)

Gene RIFs: 127   (req: > 3)

Antibodies: 388   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0