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Tbio
POR
NADPH--cytochrome P450 reductase

Protein Summary
Description
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394893
  • ENSP00000378355
  • ENSG00000127948
  • ENST00000412064
  • ENSP00000404731
  • ENST00000412521
  • ENSP00000409238
  • ENST00000414186
  • ENSP00000399327
  • ENST00000418341
  • ENSP00000389719
  • ENST00000432753
  • ENSP00000389409
  • ENST00000439963
  • ENSP00000390540
  • ENST00000449920
  • ENSP00000399556
  • ENST00000453773
  • ENSP00000395813
  • ENST00000454934
  • ENSP00000414263
  • ENST00000461988
  • ENSP00000419970

Symbol
  • CYPOR
  • CPR
  • CYPOR
  • P450R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.98
molecular function
0.98
chemical
0.97
transcription factor binding site profile
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 555.16   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 388   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 555.16   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 388   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
1
4
97
vitamin D measurement
2
1
2
93.2
cups of coffee per day measurement
2
1
2
82.5
coffee consumption measurement
2
2
2
81.5
mathematical ability
2
1
2
79
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
97
vitamin D measurement
2
93.2
cups of coffee per day measurement
2
82.5
coffee consumption measurement
2
81.5
mathematical ability
2
79
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome p450 oxidoreductase
VGNC:8738
463481
Macaque
P450 (cytochrome) oxidoreductase
715888
Mouse
MGI:97744
18984
Rat
RGD:68335
29441
Dog
cytochrome p450 oxidoreductase
VGNC:44820
489816
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome p450 oxidoreductase
Macaque
P450 (cytochrome) oxidoreductase
Mouse
Rat
Dog
cytochrome p450 oxidoreductase
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P16435-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytochrome P450 - arranged by substrate type
Metabolism
Phase I - Functionalization of compounds
Gene Ontology Terms (40)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (128)
1 – 10 of 128
SNX8
Tbio
Novelty: 0.02652492
p_int: 0.999903182
p_ni: 0.000096818
Score: 0.423
Data Source: BioPlex,STRINGDB
UBXN6
Tbio
Novelty: 0.08383376
p_int: 0.998452066
p_ni: 0.001547934
Score: 0.347
Data Source: BioPlex,STRINGDB
RARS
Tchem
Family: Enzyme
Novelty: 0.00099479
p_int: 0.953263296
p_ni: 0.046736704
Score: 0.294
Data Source: BioPlex,STRINGDB
CYB5A
Tbio
Novelty: 0.00047376
Score: 0.964
Data Source: STRINGDB
CYP7A1
Tbio
Family: Enzyme
Novelty: 0.00148194
Score: 0.949
Data Source: STRINGDB
CYP27B1
Tchem
Family: Enzyme
Novelty: 0.00147574
Score: 0.929
Data Source: STRINGDB
CYP51A1
Tchem
Family: Enzyme
Novelty: 0.00127373
Score: 0.928
Data Source: STRINGDB
CYP2R1
Tbio
Family: Enzyme
Novelty: 0.00566372
Score: 0.925
Data Source: STRINGDB
HSD3B7
Tbio
Family: Enzyme
Novelty: 0.04791842
Score: 0.911
Data Source: STRINGDB
NFE2L2
Tchem
Family: TF
Novelty: 0.00043828
Score: 0.905
Data Source: STRINGDB
Publication Statistics
PubMed Score  555.16

PubMed score by year
PubTator Score  1790.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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