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Tbio
EPCAM
Epithelial cell adhesion molecule

Protein Summary
Description
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263735
  • ENSP00000263735
  • ENSG00000119888

Symbol
  • GA733-2
  • M1S2
  • M4S1
  • MIC18
  • TACSTD1
  • TROP1
  • ESA
  • KSA
  • M4S1
  • MK-1
  • DIAR5
  • EGP-2
  • EGP40
  • KS1/4
  • MIC18
  • TROP1
  • EGP314
  • HNPCC8
  • TACSTD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.95
transcription factor perturbation
0.84
PubMedID
0.68
gene perturbation
0.67
disease
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2716.45   (req: < 5)
Gene RIFs: 250   (req: <= 3)
Antibodies: 4043   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2716.45   (req: >= 5)
Gene RIFs: 250   (req: > 3)
Antibodies: 4043   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (209)
CDH1
Tbio
Novelty:  0.00010629
Score:  0.941
Data Source:  STRINGDB
CLDN7
Tbio
Novelty:  0.00722366
Score:  0.936
Data Source:  STRINGDB
KRT19
Tbio
Novelty:  0.00043162
Score:  0.903
Data Source:  STRINGDB
CD44
Tbio
Novelty:  0.00011321
Score:  0.876
Data Source:  STRINGDB
PROM1
Tbio
Novelty:  0.00037987
Score:  0.835
Data Source:  STRINGDB
CD24
Tbio
Novelty:  0.00097222
Score:  0.834
Data Source:  STRINGDB
PTPRC
Tchem
Family:  Enzyme
Novelty:  0.00012027
Score:  0.81
Data Source:  STRINGDB
KRT8
Tbio
Novelty:  0.00093008
Score:  0.807
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.799
Data Source:  STRINGDB
KRT18
Tbio
Novelty:  0.00069055
Score:  0.779
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Cell surface interactions at the vascular wall (R-HSA-202733)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep duration
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep duration
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
epithelial cell adhesion molecule
VGNC:245
459214
Macaque
epithelial cell adhesion molecule
677680
Mouse
MGI:106653
17075
Rat
RGD:621365
171577
Dog
epithelial cell adhesion molecule
VGNC:54146
481360
Species
Name
OMA
EggNOG
Inparanoid
Chimp
epithelial cell adhesion molecule
Macaque
epithelial cell adhesion molecule
Mouse
Rat
Dog
epithelial cell adhesion molecule
Publication Statistics
PubMed Score 2716.45
PubMed score by year
PubTator Score 1295.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title