Tclin CTLA4 Cytotoxic T-lymphocyte protein 4

Protein Summary

Description

Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P16410
• A0N1S0
• E9PDH0
• O95653
• Q0PP65
• Q52MC1
• Q53TD5
• Q5S005
• Q8WXJ1
• Q96P43
• Q9UKN9

Gene Name

• CTLA4

Ensembl ID

• ENST00000295854
• ENSP00000295854
• ENSG00000163599
• ENST00000302823
• ENSP00000303939
• ENST00000472206
• ENSP00000417779
• ENST00000487393
• ENSP00000497319
• ENST00000648405
• ENSP00000497102

Symbol

• CD152
• CD
• GSE
• GRD4
• ALPS5
• CD152
• CTLA-4
• IDDM12
• CELIAC3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease	0.88
phenotype	0.82
gene perturbation	0.76
biological term	0.73
biological process	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9543.03   (req: < 5)

Gene RIFs: 1027   (req: <= 3)

Antibodies: 1282   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9543.03   (req: >= 5)

Gene RIFs: 1027   (req: > 3)

Antibodies: 1282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1