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Tclin
CTLA4
Cytotoxic T-lymphocyte protein 4

Protein Summary
Description
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295854
  • ENSP00000295854
  • ENSG00000163599
  • ENST00000302823
  • ENSP00000303939
  • ENST00000472206
  • ENSP00000417779
  • ENST00000487393
  • ENSP00000497319
  • ENST00000648405
  • ENSP00000497102

Symbol
  • CD152
  • CD
  • GSE
  • GRD4
  • ALPS5
  • CD152
  • CTLA-4
  • IDDM12
  • CELIAC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.88
phenotype
0.82
gene perturbation
0.76
biological term
0.73
biological process
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8019.44   (req: < 5)
Gene RIFs: 798   (req: <= 3)
Antibodies: 1282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8019.44   (req: >= 5)
Gene RIFs: 798   (req: > 3)
Antibodies: 1282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
ipilimumab
no chemical structure image available
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
2
2
0
1.3
89.1
1
1
0
1.4
75.8
keratinocyte carcinoma
1
1
0
1.1
50.1
5
1
2
1.1
43.2
2
1
0
1.2
35.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
0
1.3
89.1
0
1.4
75.8
keratinocyte carcinoma
0
1.1
50.1
2
1.1
43.2
0
1.2
35.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cytotoxic T-lymphocyte associated protein 4
705673
Mouse
MGI:88556
12477
Rat
RGD:61975
63835
Dog
cytotoxic T-lymphocyte associated protein 4
403696
Horse
cytotoxic T-lymphocyte associated protein 4
VGNC:51448
100067931
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cytotoxic T-lymphocyte associated protein 4
Mouse
Rat
Dog
cytotoxic T-lymphocyte associated protein 4
Horse
cytotoxic T-lymphocyte associated protein 4
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P16410-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (48)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
CTLA4 inhibitory signaling
Reactome
Costimulation by the CD28 family
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
CTLA4 inhibitory signaling
Costimulation by the CD28 family
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (16)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
MGI
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (662)
1 – 10 of 662
IL13RA1
Tbio
Novelty: 0.03308775
p_int: 0.999994164
p_ni: 0.00000187
p_wrong: 0.000003966
Score: 0.186
Data Source: BioPlex,STRINGDB
RBFA
Tbio
Novelty: 0.1061138
p_int: 0.999994136
p_ni: 0.000005863
p_wrong: 1e-9
Data Source: BioPlex
CUEDC2
Tbio
Novelty: 0.07403123
p_int: 0.999990637
p_ni: 0.000009317
p_wrong: 4.5e-8
Data Source: BioPlex
UBB
Tbio
Novelty: 0.00661254
p_int: 0.999983327
p_ni: 0.000011709
p_wrong: 0.000004965
Data Source: BioPlex
ROBO1
Tbio
Novelty: 0.00494884
p_int: 0.999972804
p_ni: 0.000026066
p_wrong: 0.000001129
Data Source: BioPlex
LETMD1
Tbio
Novelty: 0.02790517
p_int: 0.999939899
p_ni: 0.000060101
Data Source: BioPlex
PLEKHB1
Tbio
Novelty: 0.0106759
p_int: 0.999935844
p_ni: 0.000006621
p_wrong: 0.000057535
Data Source: BioPlex
BLZF1
Tbio
Novelty: 0.04344183
p_int: 0.999935115
p_ni: 0.000064862
p_wrong: 2.3e-8
Data Source: BioPlex
DGAT1
Tclin
Family: Enzyme
Novelty: 0.00121009
p_int: 0.999928432
p_ni: 0.000071537
p_wrong: 3.1e-8
Data Source: BioPlex
KIT
Tclin
Family: Kinase
Novelty: 0.00011237
p_int: 0.999913862
p_ni: 1.3e-7
p_wrong: 0.000086008
Score: 0.56
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  8019.44

PubMed score by year
PubTator Score  2733.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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