You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HIST1H1D
Histone H1.3

Protein Summary
Description
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244534
  • ENSP00000244534
  • ENSG00000124575

Symbol
  • H1F3
  • H1D
  • H1.3
  • H1F3
  • H1s-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.92
drug perturbation
0.87
transcription factor binding site profile
0.79
small molecule perturbation
0.68
cellular component
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.33   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.33   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (91)
1 – 10 of 91
RPL28
Tbio
Novelty:  0.03136035
p_int:  0.999999997
p_ni:  1e-9
p_wrong:  2e-9
Data Source:  BioPlex
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.999999993
p_ni:  6e-9
p_wrong:  1e-9
Score:  0.152
Data Source:  BioPlex,STRINGDB
HDHD2
Tdark
Family:  Enzyme
Novelty:  0.2896237
p_int:  0.999831458
p_ni:  0.000168542
Score:  0.228
Data Source:  BioPlex,STRINGDB
PMS1
Tbio
Family:  TF
Novelty:  0.00444827
p_int:  0.999415776
p_ni:  0.000584222
p_wrong:  1e-9
Score:  0.645
Data Source:  BioPlex,STRINGDB
PPA2
Tbio
Family:  Enzyme
Novelty:  0.01790138
p_int:  0.999414949
p_ni:  0.000585049
p_wrong:  2e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
ZNF662
Tdark
Family:  TF
Novelty:  2.52868181
p_int:  0.999212122
p_ni:  0.000787799
p_wrong:  7.9e-8
Score:  0.515
Data Source:  BioPlex,STRINGDB
USP38
Tbio
Family:  Enzyme
Novelty:  0.10350208
p_int:  0.998944055
p_ni:  0.001055945
Score:  0.228
Data Source:  BioPlex,STRINGDB
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.998825139
p_ni:  0.001174861
Data Source:  BioPlex
HOXB5
Tbio
Family:  TF
Novelty:  0.01119871
p_int:  0.998744979
p_ni:  0.001255021
Score:  0.229
Data Source:  BioPlex,STRINGDB
MOK
Tbio
Family:  Kinase
Novelty:  0.0116106
p_int:  0.998700899
p_ni:  0.001299062
p_wrong:  3.9e-8
Score:  0.317
Data Source:  BioPlex,STRINGDB
Pathways (9)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptosis induced DNA fragmentation
Reactome
Apoptotic execution phase
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptosis induced DNA fragmentation
Apoptotic execution phase
Cellular Senescence
Cellular responses to external stimuli
Gene Ontology Terms (17)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (47)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
11
7
11
5.6
98.7
BMI-adjusted hip circumference
3
22
31
98.2
BMI-adjusted waist circumference
6
10
20
94.1
self reported educational attainment
5
6
6
92.4
2
3
0
1.1
87.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
11
5.6
98.7
BMI-adjusted hip circumference
31
98.2
BMI-adjusted waist circumference
20
94.1
self reported educational attainment
6
92.4
0
1.1
87.3
Find similar targets by:
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histone cluster 1 H1 family member d
VGNC:14368
472227
Macaque
histone cluster 1, H1d
698238
Mouse
MGI:107502
14957
Cow
histone cluster 1, H1d
509275
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histone cluster 1 H1 family member d
Macaque
histone cluster 1, H1d
Mouse
Cow
histone cluster 1, H1d
Publication Statistics
PubMed Score 109.33
PubMed score by year
PubTator Score 50.32
PubTator score by year