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Tclin
KCNA2
Potassium voltage-gated channel subfamily A member 2

Protein Summary
Description
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559, PubMed:11211111, PubMed:23769686). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559, PubMed:20220134). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316361
  • ENSP00000314520
  • ENSG00000177301
  • ENST00000369770
  • ENSP00000358785
  • ENST00000485317
  • ENSP00000433109
  • ENST00000633222
  • ENSP00000487785
  • ENST00000638532
  • ENSP00000491613
  • ENST00000638616
  • ENSP00000491977

Symbol
  • HK4
  • MK2
  • HBK5
  • NGK1
  • RBK2
  • HUKIV
  • KV1.2
  • EIEE32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
gene perturbation
0.95
molecular function
0.86
cellular component
0.71
transcription factor
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 592.32   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 592.32   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
6.3
electrocardiography
1
1
1
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
6.3
electrocardiography
1
0.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96659
16490
Rat
RGD:2950
25468
Dog
potassium voltage-gated channel subfamily A member 2
VGNC:42229
404022
Horse
potassium voltage-gated channel subfamily A member 2
VGNC:19261
100058705
Cow
potassium voltage-gated channel subfamily A member 2
VGNC:30422
539608
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
potassium voltage-gated channel subfamily A member 2
Horse
potassium voltage-gated channel subfamily A member 2
Cow
potassium voltage-gated channel subfamily A member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P16389-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Gene Ontology Terms (30)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (239)
1 – 10 of 239
KCNAB2
Tbio
Family: IC
Novelty: 0.01752175
Score: 0.997
Data Source: STRINGDB
KCNAB1
Tbio
Family: IC
Novelty: 0.01413705
Score: 0.994
Data Source: STRINGDB
KCNAB3
Tbio
Family: IC
Novelty: 0.10128237
Score: 0.971
Data Source: STRINGDB
CTTN
Tbio
Novelty: 0.0017962
Score: 0.962
Data Source: STRINGDB
CNTNAP2
Tbio
Novelty: 0.00238905
Score: 0.894
Data Source: STRINGDB
CNTNAP1
Tbio
Novelty: 0.00618741
Score: 0.884
Data Source: STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.85
Data Source: STRINGDB
SCN8A
Tclin
Family: IC
Novelty: 0.00203805
Score: 0.806
Data Source: STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.788
Data Source: STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.788
Data Source: STRINGDB
Publication Statistics
PubMed Score  592.32

PubMed score by year
PubTator Score  220.73

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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