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Tbio
NCK1
Cytoplasmic protein NCK1

Protein Summary
Description
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288986
  • ENSP00000288986
  • ENSG00000158092
  • ENST00000469404
  • ENSP00000419631
  • ENST00000481752
  • ENSP00000417273

Symbol
  • NCK
  • NCK
  • nck-1
  • NCKalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase perturbation
0.95
hub protein
0.92
histone modification site profile
0.9
molecular function
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.94   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 529   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.94   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 529   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
71.3
blood urea nitrogen measurement
1
1
1
47.6
neutrophil count
1
1
1
41.8
platelet count
1
1
1
36.5
neuroticism measurement
1
1
0
5.5
7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
71.3
blood urea nitrogen measurement
1
47.6
neutrophil count
1
41.8
platelet count
1
36.5
neuroticism measurement
0
5.5
7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NCK adaptor protein 1
VGNC:2438
460720
Mouse
MGI:109601
17973
Rat
RGD:1310688
300955
Dog
NCK adaptor protein 1
VGNC:52892
485677
Horse
NCK adaptor protein 1
VGNC:52413
100053397
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NCK adaptor protein 1
Mouse
Rat
Dog
NCK adaptor protein 1
Horse
NCK adaptor protein 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P16333-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (63)
Activation of RAC1 (R-HSA-428540)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of RAC1
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Axon guidance
Reactome
Cell-Cell communication
Name
Explore in Pharos
Explore in Source
Activation of RAC1
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Axon guidance
Cell-Cell communication
Gene Ontology Terms (47)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
FlyBase
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
ParkinsonsUK-UCL
Inferred by Curator (IC)
ParkinsonsUK-UCL
Protein-Protein Interactions (309)
1 – 10 of 309
WIPF1
Tbio
Novelty: 0.00427982
p_int: 1
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
PIK3AP1
Tbio
Family: Enzyme
Novelty: 0.11565645
p_int: 0.999999999
p_ni: 1e-9
Score: 0.92
Data Source: BioPlex,STRINGDB
WASL
Tbio
Novelty: 0.0029314
p_int: 0.999999997
p_ni: 3e-9
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
WIPF2
Tbio
Novelty: 0.11973409
p_int: 0.999999996
p_ni: 4e-9
Score: 0.959
Data Source: BioPlex,Reactome,STRINGDB
SOS2
Tbio
Novelty: 0.01607832
p_int: 0.999999975
p_ni: 7e-9
p_wrong: 1.8e-8
Score: 0.923
Data Source: BioPlex,Reactome,STRINGDB
TNK2
Tclin
Family: Kinase
Novelty: 0.00921397
p_int: 0.999999964
p_ni: 3.4e-8
p_wrong: 1e-9
Score: 0.658
Data Source: BioPlex,STRINGDB
KIAA1522
Tdark
Novelty: 0.15028395
p_int: 0.99999995
p_ni: 5e-8
Data Source: BioPlex
ARAP1
Tbio
Novelty: 0.0479494
p_int: 0.999999928
p_ni: 7.2e-8
Data Source: BioPlex
SOS1
Tbio
Novelty: 0.00285343
p_int: 0.999999904
p_ni: 9.5e-8
Score: 0.96
Data Source: BioPlex,Reactome,STRINGDB
WIPF3
Tdark
Novelty: 0.0257625
p_int: 0.999999839
p_ni: 1.31e-7
p_wrong: 3e-8
Score: 0.947
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  284.94

PubMed score by year
PubTator Score  145.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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