Tbio PPP3CB Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Protein Summary

Description

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:26794871). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138).

Uniprot Accession IDs

• P16298
• P16299
• Q5F2F9
• Q8N1F0
• Q8N3W4

Gene Name

• PPP3CB

Ensembl ID

• ENST00000360663
• ENSP00000353881
• ENSG00000107758
• ENST00000394828
• ENSP00000378305
• ENST00000394829
• ENSP00000378306

Symbol

• CALNA2
• CALNB
• CNA2
• CNA2
• CALNB
• CALNA2
• PP2Bbeta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
biological process	0.99
kinase perturbation	0.99
virus perturbation	0.92
interacting protein	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.27   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 184   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.27   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0