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Tbio
PPP3CB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Protein Summary
Description
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:26794871). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360663
  • ENSP00000353881
  • ENSG00000107758
  • ENST00000394828
  • ENSP00000378305
  • ENST00000394829
  • ENSP00000378306

Symbol
  • CALNA2
  • CALNB
  • CNA2
  • CNA2
  • CALNB
  • CALNA2
  • PP2Bbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
biological process
0.99
kinase perturbation
0.99
virus perturbation
0.92
interacting protein
0.82


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.61   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.61   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 3 catalytic subunit beta
VGNC:7858
450898
Macaque
protein phosphatase 3 catalytic subunit beta [Source:HGNC Symbol;Acc:HGNC:9315]
Mouse
MGI:107163
19056
Rat
RGD:3383
24675
Dog
protein phosphatase 3 catalytic subunit beta
VGNC:44919
479248
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 3 catalytic subunit beta
Macaque
protein phosphatase 3 catalytic subunit beta [Source:HGNC Symbol;Acc:HGNC:9315]
Mouse
Rat
Dog
protein phosphatase 3 catalytic subunit beta
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (70)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Beta-catenin independent WNT signaling
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) induces NFAT activation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Beta-catenin independent WNT signaling
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) induces NFAT activation
Gene Ontology Terms (45)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (235)
1 – 10 of 235
RCAN1
Tbio
Novelty: 0.0030009
p_int: 0.999982418
p_ni: 0.000017582
Score: 0.846
Data Source: BioPlex,STRINGDB
PPP3R2
Tbio
Novelty: 0.01121867
p_int: 0.999958137
p_ni: 0.000041864
Score: 0.97
Data Source: BioPlex,STRINGDB
RCAN3
Tbio
Novelty: 0.12819457
p_int: 0.999887007
p_ni: 0.000112993
Score: 0.922
Data Source: BioPlex,STRINGDB
TMEM200A
Tdark
Novelty: 0.25580793
p_int: 0.999843512
p_ni: 0.000156488
Score: 0.552
Data Source: BioPlex,STRINGDB
TNS4
Tbio
Novelty: 0.048713
p_int: 0.999666361
p_ni: 0.00033364
Data Source: BioPlex
PDHB
Tbio
Family: Enzyme
Novelty: 0.01018086
p_int: 0.999150471
p_ni: 0.000849529
Score: 0.631
Data Source: BioPlex,STRINGDB
RCAN2
Tbio
Novelty: 0.00174006
p_int: 0.998958804
p_ni: 0.001041196
Score: 0.848
Data Source: BioPlex,STRINGDB
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.998697544
p_ni: 0.001302456
Data Source: BioPlex
GSK3A
Tclin
Family: Kinase
Novelty: 0.00925708
p_int: 0.993212468
p_ni: 0.006787532
Score: 0.355
Data Source: BioPlex,STRINGDB
PPP3CC
Tbio
Family: Enzyme
Novelty: 0.02633046
p_int: 0.973471029
p_ni: 0.026528971
Score: 0.982
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  37.61

PubMed score by year
PubTator Score  20.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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