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Tbio
PECAM1
Platelet endothelial cell adhesion molecule

Protein Classes
Protein Summary
Description
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMe ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
biological term
0.92
gene perturbation
0.86
hub protein
0.85
tissue sample
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6912.09   (req: < 5)
Gene RIFs: 216   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6912.09   (req: >= 5)
Gene RIFs: 216   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
82.4
3
3
2
1.1
72.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
82.4
2
1.1
72.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
platelet and endothelial cell adhesion molecule 1
VGNC:9506
454766
Macaque
platelet and endothelial cell adhesion molecule 1
718302
Mouse
MGI:97537
18613
Dog
platelet and endothelial cell adhesion molecule 1
VGNC:44410
610775
Horse
platelet and endothelial cell adhesion molecule 1
VGNC:21301
100064309
Species
Name
OMA
EggNOG
Inparanoid
Chimp
platelet and endothelial cell adhesion molecule 1
Macaque
platelet and endothelial cell adhesion molecule 1
Mouse
Dog
platelet and endothelial cell adhesion molecule 1
Horse
platelet and endothelial cell adhesion molecule 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P16284-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Extracellular matrix organization
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Extracellular matrix organization
Hemostasis
Immune System
Innate Immune System
Gene Ontology Terms (32)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (424)
1 – 10 of 424
LGALS1
Tchem
Novelty: 0.00106509
p_int: 0.987617048
p_ni: 0.012382788
p_wrong: 1.64e-7
Score: 0.379
Data Source: BioPlex,STRINGDB
CDH5
Tbio
Novelty: 0.00072649
Score: 0.988
Data Source: STRINGDB
KDR
Tclin
Family: Kinase
Novelty: 0.00016219
Score: 0.984
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.982
Data Source: STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.982
Data Source: Reactome,STRINGDB
ITGB3
Tclin
Novelty: 0.00067255
Score: 0.973
Data Source: Reactome,STRINGDB
LYN
Tclin
Family: Kinase
Novelty: 0.00097393
Score: 0.966
Data Source: STRINGDB
CD177
Tbio
Novelty: 0.00197563
Score: 0.964
Data Source: Reactome,STRINGDB
ITGAV
Tchem
Novelty: 0.00148589
Score: 0.956
Data Source: Reactome,STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
Score: 0.955
Data Source: STRINGDB
Publication Statistics
PubMed Score  6912.09

PubMed score by year
PubTator Score  3005.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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