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Tclin
PDGFRA
Platelet-derived growth factor receptor alpha

Protein Summary
Description
Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of sever ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257290
  • ENSP00000257290
  • ENSG00000134853
  • ENST00000508170
  • ENSP00000425648
  • ENST00000509490
  • ENSP00000424218

Symbol
  • PDGFR2
  • RHEPDGFRA
  • CD140A
  • PDGFR2
  • PDGFR-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
PubMedID
0.99
transcription factor perturbation
0.94


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1352.33   (req: < 5)
Gene RIFs: 363   (req: <= 3)
Antibodies: 1853   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1352.33   (req: >= 5)
Gene RIFs: 363   (req: > 3)
Antibodies: 1853   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 62
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 129
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12
Approved Drugs (12)
1 – 10 of 12
sunitinib
chemical structure image
dasatinib
chemical structure image
nintedanib
chemical structure image
imatinib
chemical structure image
pazopanib
chemical structure image
axitinib
chemical structure image
lenvatinib
chemical structure image
quizartinib
chemical structure image
tivozanib
chemical structure image
avapritinib
chemical structure image
Active Ligands (129)
1 – 10 of 129
CHEMBL388978
chemical structure image
CHEMBL1230609
chemical structure image
CHEMBL574738
chemical structure image
CHEMBL386051
chemical structure image
CHEMBL1908395,CHEMBL1908842
chemical structure image
CHEMBL2347053
chemical structure image
CHEMBL522892
chemical structure image
CHEMBL1784637
chemical structure image
CHEMBL1980297
chemical structure image
CHEMBL491473
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Astigmatism
1
1
0
1.3
43.3
cup-to-disc ratio measurement
1
1
1
41.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Astigmatism
0
1.3
43.3
cup-to-disc ratio measurement
1
41.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
platelet derived growth factor receptor alpha
461318
Macaque
platelet derived growth factor receptor alpha [Source:HGNC Symbol;Acc:HGNC:8803]
Mouse
MGI:97530
18595
Rat
RGD:3284
25267
Dog
platelet derived growth factor receptor alpha
VGNC:44372
442860
Species
Name
OMA
EggNOG
Inparanoid
Chimp
platelet derived growth factor receptor alpha
Macaque
platelet derived growth factor receptor alpha [Source:HGNC Symbol;Acc:HGNC:8803]
Mouse
Rat
Dog
platelet derived growth factor receptor alpha
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (70)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downstream signal transduction
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Downstream signal transduction
Gene Ontology Terms (75)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (296)
1 – 10 of 296
PDGFRB
Tclin
Family: Kinase
Novelty: 0.00074896
p_int: 0.978274992
p_ni: 0.000070685
p_wrong: 0.021654323
Score: 0.955
Data Source: BioPlex,Reactome,STRINGDB
PDGFA
Tchem
Novelty: 0.00155768
Score: 0.988
Data Source: Reactome,STRINGDB
PIK3R1
Tchem
Family: Kinase
Novelty: 0.00179772
Score: 0.985
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.981
Data Source: STRINGDB
PDGFB
Tchem
Novelty: 0.00080876
Score: 0.98
Data Source: Reactome,STRINGDB
PIK3CA
Tclin
Family: Kinase
Novelty: 0.00044273
Score: 0.978
Data Source: Reactome,STRINGDB
PDGFC
Tbio
Novelty: 0.00642236
Score: 0.977
Data Source: STRINGDB
CRK
Tbio
Novelty: 0.00238512
Score: 0.975
Data Source: Reactome,STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.0003383
Score: 0.973
Data Source: STRINGDB
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
Score: 0.973
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1352.33

PubMed score by year
PubTator Score  1196.8

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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