You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
PDGFRA
Platelet-derived growth factor receptor alpha

Protein Summary
Description
Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of sever ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257290
  • ENSP00000257290
  • ENSG00000134853
  • ENST00000508170
  • ENSP00000425648
  • ENST00000509490
  • ENSP00000424218

Symbol
  • PDGFR2
  • RHEPDGFRA
  • CD140A
  • PDGFR2
  • PDGFR-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
PubMedID
0.99
transcription factor perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1601.41   (req: < 5)
Gene RIFs: 416   (req: <= 3)
Antibodies: 1853   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1601.41   (req: >= 5)
Gene RIFs: 416   (req: > 3)
Antibodies: 1853   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 62
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 190
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 14