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Tclin
PNLIP
Pancreatic triacylglycerol lipase

Protein Summary
Description
This gene encodes a member of the lipase family of proteins. The encoded enzyme is secreted by the pancreas and hydrolyzes triglycerides in the small intestine, and is essential for the efficient digestion of dietary fats. Inhibition of the encoded enzyme may prevent high-fat diet-induced obesity in mice and result in weight loss in human patients with obesity. Mutations in this gene cause congenital pancreatic lipase deficiency, a rare disorder characterized by steatorrhea. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369221
  • ENSP00000358223
  • ENSG00000175535

Symbol
  • PL
  • PTL
  • PNLIPD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
protein domain
0.92
gene perturbation
0.65
cell type or tissue
0.63
biological process
0.52


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2281.73   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 433   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2281.73   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 433   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
orlistat
chemical structure image
cetilistat
chemical structure image
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pancreatic lipase
VGNC:7855
739640
Macaque
pancreatic lipase
706689
Mouse
MGI:97722
69060
Rat
RGD:3360
25702
Horse
pancreatic lipase
100034202
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pancreatic lipase
Macaque
pancreatic lipase
Mouse
Rat
Horse
pancreatic lipase
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P16233-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion
Reactome
Digestion and absorption
Reactome
Digestion of dietary lipid
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Digestion
Digestion and absorption
Digestion of dietary lipid
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (118)
1 – 10 of 118
PNLIPRP2
Tbio
Family: Enzyme
p_int: 0.999999997
p_wrong: 3e-9
Data Source: BioPlex
ETNK1
Tbio
Family: Kinase
Novelty: 0.04817798
p_int: 0.999991136
p_ni: 0.000008863
p_wrong: 1e-9
Score: 0.243
Data Source: BioPlex,STRINGDB
ZNF444
Tdark
Family: TF
Novelty: 0.21564163
p_int: 0.997380087
p_ni: 0.002619913
Score: 0.186
Data Source: BioPlex,STRINGDB
SUMF1
Tbio
Family: Enzyme
Novelty: 0.00954537
p_int: 0.994232692
p_ni: 0.005765347
p_wrong: 0.00000196
Score: 0.189
Data Source: BioPlex,STRINGDB
ZGPAT
Tbio
Family: Epigenetic
Novelty: 0.16971298
p_int: 0.977580384
p_ni: 0.022414059
p_wrong: 0.000005557
Score: 0.188
Data Source: BioPlex,STRINGDB
ZNF787
Tdark
Family: TF
Novelty: 0.11251187
p_int: 0.938881474
p_ni: 0.00012177
p_wrong: 0.060996756
Score: 0.403
Data Source: BioPlex,STRINGDB
RSAD1
Tdark
Novelty: 0.63344405
p_int: 0.870073608
p_ni: 0.129926392
Score: 0.23
Data Source: BioPlex,STRINGDB
LAMC1
Tbio
Novelty: 0.01230796
p_int: 0.75985577
p_ni: 0.24014423
Score: 0.214
Data Source: BioPlex,STRINGDB
CLPS
Tbio
Family: Enzyme
Novelty: 0.00246852
Score: 0.997
Data Source: Reactome,STRINGDB
CEL
Tchem
Family: Enzyme
Novelty: 0.00156761
Score: 0.96
Data Source: STRINGDB
Publication Statistics
PubMed Score  2281.73

PubMed score by year
PubTator Score  348.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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