Tbio CREB1 Cyclic AMP-responsive element-binding protein 1

Protein Summary

Description

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• P16220
• P21934
• Q6V963
• Q9UMA7
• CREB-1

Gene Name

• CREB1

Ensembl ID

• ENST00000353267
• ENSP00000236995
• ENSG00000118260
• ENST00000430624
• ENSP00000405539
• ENST00000432329
• ENSP00000387699

Symbol

• CREB
• CREB-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
chemical	1
hub protein	1
kinase	1

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5886.43   (req: < 5)

Gene RIFs: 539   (req: <= 3)

Antibodies: 2012   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5886.43   (req: >= 5)

Gene RIFs: 539   (req: > 3)

Antibodies: 2012   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 65

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0