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Tbio
CREB1
Cyclic AMP-responsive element-binding protein 1

Protein Summary
Description
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353267
  • ENSP00000236995
  • ENSG00000118260
  • ENST00000430624
  • ENSP00000405539
  • ENST00000432329
  • ENSP00000387699

Symbol
  • CREB
  • CREB-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
hub protein
1
kinase
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5347.24   (req: < 5)
Gene RIFs: 440   (req: <= 3)
Antibodies: 2012   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5347.24   (req: >= 5)
Gene RIFs: 440   (req: > 3)
Antibodies: 2012   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 65
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
85.5
testosterone measurement
1
1
1
47.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
85.5
testosterone measurement
1
47.1
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (201)
AKT phosphorylates targets in the nucleus (R-HSA-198693)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 81
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the nucleus
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Axon guidance
Reactome
CREB phosphorylation
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the nucleus
Activation of NMDA receptors and postsynaptic events
Axon guidance
CREB phosphorylation
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Gene Ontology Terms (72)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (629)
1 – 10 of 629
CTAGE5
Tbio
Novelty: 0.04516631
p_int: 0.999665234
p_ni: 0.000334766
Data Source: BioPlex
TUFT1
Tbio
Novelty: 0.01999031
p_int: 0.987745886
p_ni: 0.012254114
Score: 0.198
Data Source: BioPlex,STRINGDB
ARIH1
Tbio
Family: Enzyme
Novelty: 0.0258739
p_int: 0.973113495
p_ni: 0.026884797
p_wrong: 0.000001708
Score: 0.152
Data Source: BioPlex,STRINGDB
ORC6
Tbio
Novelty: 0.02529139
p_int: 0.952121796
p_ni: 0.047877071
p_wrong: 0.000001132
Score: 0.163
Data Source: BioPlex,STRINGDB
ARHGAP22
Tbio
Family: Enzyme
Novelty: 0.13037853
p_int: 0.929605106
p_ni: 0.070394132
p_wrong: 7.62e-7
Data Source: BioPlex
NFIL3
Tbio
Family: TF
Novelty: 0.00882074
p_int: 0.898958695
p_ni: 0.101041303
p_wrong: 2e-9
Score: 0.722
Data Source: BioPlex,STRINGDB
TRPV5
Tchem
Family: IC
Novelty: 0.0055156
p_int: 0.897855263
p_ni: 0.102144569
p_wrong: 1.68e-7
Score: 0.211
Data Source: BioPlex,STRINGDB
TRIM5
Tbio
Novelty: 0.00289445
p_int: 0.880856231
p_ni: 0.119125166
p_wrong: 0.000018603
Score: 0.242
Data Source: BioPlex,STRINGDB
C16orf71
Tdark
Novelty: 0.97826087
p_int: 0.864460238
p_ni: 0.135539667
p_wrong: 9.5e-8
Data Source: BioPlex
FEZ1
Tbio
Novelty: 0.02695814
p_int: 0.862326762
p_ni: 0.137673195
p_wrong: 4.3e-8
Score: 0.158
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  5347.24

PubMed score by year
PubTator Score  2205.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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