Protein Summary
Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. Isoform Mu17 together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically co ...more
- ENST00000265709
- ENSP00000265709
- ENSG00000029534
- ENST00000289734
- ENSP00000289734
- ENST00000314214
- ENSP00000319123
- ENST00000347528
- ENSP00000339620
- ENST00000348036
- ENSP00000297744
- ENST00000522543
- ENSP00000430368
- ANK
- ANK
- SPH1
- SPH2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 1 | ||
trait | 1 | ||
disease perturbation | 0.93 | ||
transcription factor perturbation | 0.88 | ||
disease | 0.81 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 335.22 (req: < 5)
Gene RIFs: 43 (req: <= 3)
Antibodies: 363 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 335.22 (req: >= 5)
Gene RIFs: 43 (req: > 3)
Antibodies: 363 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
5 | 3 | 1 | 1.1 | 96.3 | |||||
HbA1c measurement | 6 | 3 | 8 | 96.2 | |||||
red blood cell distribution width | 4 | 6 | 9 | 93.5 | |||||
mean corpuscular hemoglobin concentration | 2 | 4 | 4 | 92.4 | |||||
birth weight | 4 | 1 | 4 | 90 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 1.1 | 96.3 | |||||
HbA1c measurement | 8 | 96.2 | |||||
red blood cell distribution width | 9 | 93.5 | |||||
mean corpuscular hemoglobin concentration | 4 | 92.4 | |||||
birth weight | 4 | 90 | |||||
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (16)
Reactome (15)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 15
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Axon guidance | ||||
Reactome | CHL1 interactions | ||||
Reactome | COPI-mediated anterograde transport | ||||
Reactome | Developmental Biology | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Axon guidance | ||||
CHL1 interactions | ||||
COPI-mediated anterograde transport | ||||
Developmental Biology | ||||
Gene Ontology Terms (30)
Functions (8)
Components (15)
Processes (7)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Protein-Protein Interactions (167)
1 – 10 of 167
RAPGEF5
Novelty: 0.02449802
p_int: 0.999999879
p_ni: 1.03e-7
p_wrong: 1.8e-8
Score: 0.259
Data Source: BioPlex,STRINGDB
CHL1
Novelty: 0.00055237
p_int: 0.999998813
p_ni: 0.000001187
Score: 0.942
Data Source: BioPlex,Reactome,STRINGDB
FIG4
Family: Enzyme
Novelty: 0.00742268
p_int: 0.999959465
p_ni: 0.000040524
p_wrong: 1.1e-8
Score: 0.842
Data Source: BioPlex,STRINGDB
PIKFYVE
Family: Kinase
Novelty: 0.00441336
p_int: 0.999957701
p_ni: 0.000042299
Score: 0.867
Data Source: BioPlex,STRINGDB
PPP1R12B
Family: Enzyme
Novelty: 0.0424259
p_int: 0.999761219
p_ni: 0.000087032
p_wrong: 0.000151749
Data Source: BioPlex
MB
Novelty: 0.00008405
p_int: 0.995671066
p_ni: 0.003466394
p_wrong: 0.000862541
Score: 0.265
Data Source: BioPlex,STRINGDB
PDS5B
Novelty: 0.00295057
p_int: 0.993672137
p_ni: 0.006327851
p_wrong: 1.2e-8
Score: 0.194
Data Source: BioPlex,STRINGDB
VAC14
Novelty: 0.02677738
p_int: 0.978973006
p_ni: 0.021026994
Score: 0.768
Data Source: BioPlex,STRINGDB
NELFB
Novelty: 0.05821821
p_int: 0.932192192
p_ni: 0.067047519
p_wrong: 0.000760289
Score: 0.224
Data Source: BioPlex,STRINGDB
ITGAM
Novelty: 0.00017521
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score 335.22
PubMed score by year
PubTator Score 265.45
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
GWAS Trait