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Tbio
ANK1
Ankyrin-1

Protein Summary
Description
Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. Isoform Mu17 together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically co ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265709
  • ENSP00000265709
  • ENSG00000029534
  • ENST00000289734
  • ENSP00000289734
  • ENST00000314214
  • ENSP00000319123
  • ENST00000347528
  • ENSP00000339620
  • ENST00000348036
  • ENSP00000297744
  • ENST00000522543
  • ENSP00000430368

Symbol
  • ANK
  • ANK
  • SPH1
  • SPH2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
1
trait
1
disease perturbation
0.93
transcription factor perturbation
0.88
disease
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.22   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 363   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.22   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 363   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
1
1.1
96.3
HbA1c measurement
6
3
8
96.2
red blood cell distribution width
4
6
9
93.5
mean corpuscular hemoglobin concentration
2
4
4
92.4
birth weight
4
1
4
90
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
96.3
HbA1c measurement
8
96.2
red blood cell distribution width
9
93.5
mean corpuscular hemoglobin concentration
4
92.4
birth weight
4
90
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Axon guidance
Reactome
CHL1 interactions
Reactome
COPI-mediated anterograde transport
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Axon guidance
CHL1 interactions
COPI-mediated anterograde transport
Developmental Biology
Gene Ontology Terms (30)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (167)
1 – 10 of 167
RAPGEF5
Tbio
Novelty: 0.02449802
p_int: 0.999999879
p_ni: 1.03e-7
p_wrong: 1.8e-8
Score: 0.259
Data Source: BioPlex,STRINGDB
CHL1
Tbio
Novelty: 0.00055237
p_int: 0.999998813
p_ni: 0.000001187
Score: 0.942
Data Source: BioPlex,Reactome,STRINGDB
FIG4
Tbio
Family: Enzyme
Novelty: 0.00742268
p_int: 0.999959465
p_ni: 0.000040524
p_wrong: 1.1e-8
Score: 0.842
Data Source: BioPlex,STRINGDB
PIKFYVE
Tchem
Family: Kinase
Novelty: 0.00441336
p_int: 0.999957701
p_ni: 0.000042299
Score: 0.867
Data Source: BioPlex,STRINGDB
PPP1R12B
Tbio
Family: Enzyme
Novelty: 0.0424259
p_int: 0.999761219
p_ni: 0.000087032
p_wrong: 0.000151749
Data Source: BioPlex
MB
Tbio
Novelty: 0.00008405
p_int: 0.995671066
p_ni: 0.003466394
p_wrong: 0.000862541
Score: 0.265
Data Source: BioPlex,STRINGDB
PDS5B
Tbio
Novelty: 0.00295057
p_int: 0.993672137
p_ni: 0.006327851
p_wrong: 1.2e-8
Score: 0.194
Data Source: BioPlex,STRINGDB
VAC14
Tbio
Novelty: 0.02677738
p_int: 0.978973006
p_ni: 0.021026994
Score: 0.768
Data Source: BioPlex,STRINGDB
NELFB
Tbio
Novelty: 0.05821821
p_int: 0.932192192
p_ni: 0.067047519
p_wrong: 0.000760289
Score: 0.224
Data Source: BioPlex,STRINGDB
ITGAM
Tbio
Novelty: 0.00017521
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  335.22

PubMed score by year
PubTator Score  265.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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