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Tchem
CBR1
Carbonyl reductase [NADPH] 1

Protein Summary
Description
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290349
  • ENSP00000290349
  • ENSG00000159228
  • ENST00000530908
  • ENSP00000434613

Symbol
  • CBR
  • CRN
  • SDR21C1
  • CBR
  • hCBR1
  • SDR21C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
gene perturbation
0.93
virus perturbation
0.85
protein complex
0.73
chemical
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.56   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 414   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.56   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
triclosan
Rendered image for triclosan
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
3
3
92.4
C-reactive protein measurement
1
1
1
11.1
Mitral valve prolapse
1
1
0
1.2
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
3
92.4
C-reactive protein measurement
1
11.1
Mitral valve prolapse
0
1.2
2.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbonyl reductase 1
VGNC:14651
473983
Macaque
carbonyl reductase [NADPH] 1
699655
Mouse
MGI:88284
12408
Rat
RGD:7631561
102556347
Dog
carbonyl reductase [NADPH] 1
610164
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbonyl reductase 1
Macaque
carbonyl reductase [NADPH] 1
Mouse
Rat
Dog
carbonyl reductase [NADPH] 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P16152-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Fatty acid metabolism
Metabolism
Metabolism of lipids
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (78)
1 – 10 of 78
CBR3
Tbio
Family:  Enzyme
Novelty:  0.01874422
p_int:  0.903060658
p_ni:  0.096939342
Score:  0.947
Data Source:  BioPlex,STRINGDB
SPR
Tchem
Family:  Enzyme
Novelty:  0.02144934
Score:  0.973
Data Source:  STRINGDB
DHFR
Tclin
Family:  Enzyme
Novelty:  0.00074557
Score:  0.971
Data Source:  STRINGDB
AKR1C3
Tchem
Family:  Enzyme
Novelty:  0.00257785
Score:  0.966
Data Source:  STRINGDB
PTGES
Tchem
Family:  Enzyme
Novelty:  0.00146096
Score:  0.943
Data Source:  STRINGDB
PTGES2
Tchem
Family:  Enzyme
Novelty:  0.01415352
Score:  0.927
Data Source:  STRINGDB
CYP3A4
Tclin
Family:  Enzyme
Novelty:  0.00015515
Score:  0.927
Data Source:  STRINGDB
PTS
Tbio
Family:  Enzyme
Novelty:  0.00279396
Score:  0.926
Data Source:  STRINGDB
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
Score:  0.919
Data Source:  STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
Score:  0.918
Data Source:  STRINGDB
Publication Statistics
PubMed Score  178.56

PubMed score by year
PubTator Score  365.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer