Tbio ITGB4 Integrin beta-4

Protein Summary

Description

Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P16144
• A0AVL6
• O14690
• O14691
• O15339
• O15340
• O15341
• Q0VF97
• Q9UIQ4

Gene Name

• ITGB4

Ensembl ID

• ENST00000200181
• ENSP00000200181
• ENSG00000132470
• ENST00000449880
• ENSP00000400217
• ENST00000450894
• ENSP00000405536
• ENST00000579662
• ENSP00000463651

Symbol

• CD104
• GP150

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
hub protein	0.99
interacting protein	0.91
biological term	0.84
kinase	0.72

Protein Classes

PANTHER Classes

Protein / Receptor / Integrin Beta-4

Protein / Cell Adhesion Molecule / Integrin Beta-4

DTO Classes

Protein / Receptor / Integrin Beta-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.7   (req: < 5)

Gene RIFs: 195   (req: <= 3)

Antibodies: 967   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.7   (req: >= 5)

Gene RIFs: 195   (req: > 3)

Antibodies: 967   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0