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Tbio
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

Protein Summary
Description
Synthesis and degradation of fructose 2,6-bisphosphate. This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375006
  • ENSP00000364145
  • ENSG00000158571
  • ENST00000545676
  • ENSP00000444074

Symbol
  • F6PK
  • PFRX
  • F6PK
  • HL2K
  • PFRX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.85
biological process
0.79
gene perturbation
0.76
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.5   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.5   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
PRKACA
Tchem
Family:  Kinase
Novelty:  0.03869658
Score:  0.96
Data Source:  Reactome,STRINGDB
TIGAR
Tbio
Family:  Enzyme
Novelty:  0.0090389
Score:  0.958
Data Source:  STRINGDB
PRKACG
Tchem
Family:  Kinase
Novelty:  0.11080061
Score:  0.939
Data Source:  Reactome,STRINGDB
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
Score:  0.939
Data Source:  Reactome,STRINGDB
PFKFB3
Tchem
Family:  Kinase
Novelty:  0.00333471
Score:  0.928
Data Source:  STRINGDB
PFKFB4
Tchem
Family:  Enzyme
Novelty:  0.02847966
Score:  0.918
Data Source:  STRINGDB
MPI
Tchem
Family:  Enzyme
Novelty:  0.0091718
Score:  0.916
Data Source:  STRINGDB
PFKM
Tbio
Family:  Kinase
Novelty:  0.00217816
Score:  0.906
Data Source:  STRINGDB
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
Score:  0.903
Data Source:  STRINGDB
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
Score:  0.903
Data Source:  STRINGDB
Pathways (14)
Glucose metabolism (R-HSA-70326)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Integration of energy metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glucose metabolism
Glycolysis
Integration of energy metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
3
3
81.7
red blood cell distribution width
1
1
1
73.7
mean reticulocyte volume
1
2
2
69.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
81.7
red blood cell distribution width
1
73.7
mean reticulocyte volume
2
69.3
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
701969
Mouse
MGI:107816
18639
Rat
RGD:3307
24638
Dog
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
VGNC:44442
491903
Horse
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
VGNC:21337
100062514
Species
Name
OMA
EggNOG
Inparanoid
Macaque
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Mouse
Rat
Dog
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Horse
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Publication Statistics
PubMed Score 22.50
PubMed score by year
PubTator Score 19.13
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title