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Tbio
H2AFX
Histone H2AX

Protein Summary
Description
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating u ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375167
  • ENSP00000364310
  • ENSG00000188486
  • ENST00000530167
  • ENSP00000434024

Symbol
  • H2AX
  • H2AX
  • H2A.X
  • H2A/X
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
1
hub protein
1
phosphatase
1
transcription factor binding site profile
0.98


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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1904.67   (req: < 5)
Gene RIFs: 277   (req: <= 3)
Antibodies: 1394   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1904.67   (req: >= 5)
Gene RIFs: 277   (req: > 3)
Antibodies: 1394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
54.7
glomerular filtration rate
1
1
1
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
54.7
glomerular filtration rate
1
3.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
H2A histone family member X
VGNC:12576
104001345
Mouse
MGI:102688
15270
Rat
RGD:1566119
500987
Dog
histone H2AX
489372
Cow
H2A histone family, member X
531733
Species
Name
OMA
EggNOG
Inparanoid
Chimp
H2A histone family member X
Mouse
Rat
Dog
histone H2AX
Cow
H2A histone family, member X
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P16104-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (97)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 83
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Gene Ontology Terms (33)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (689)
1 – 10 of 689
HIST1H2BD
Tbio
Novelty: 0.05094332
p_int: 1
Score: 0.97
Data Source: BioPlex,STRINGDB
HIST1H2BO
Tdark
Novelty: 0.3427419
p_int: 1
Score: 0.96
Data Source: BioPlex,STRINGDB
GON4L
Tbio
Novelty: 0.06166736
p_int: 0.999999856
p_ni: 1.44e-7
Data Source: BioPlex
TONSL
Tbio
Novelty: 0.07220129
p_int: 0.999999552
p_ni: 4.48e-7
Score: 0.276
Data Source: BioPlex,STRINGDB
HIST1H1C
Tbio
Novelty: 0.00415337
p_int: 0.999999496
p_ni: 5.04e-7
Score: 0.541
Data Source: BioPlex,STRINGDB
PHF14
Tbio
Family: Epigenetic
Novelty: 0.13279118
p_int: 0.999999118
p_ni: 8.81e-7
Score: 0.35
Data Source: BioPlex,STRINGDB
MMS22L
Tbio
Novelty: 0.22570578
p_int: 0.999998215
p_ni: 0.000001785
Score: 0.241
Data Source: BioPlex,STRINGDB
HIST1H1T
Tdark
Novelty: 0.01039464
p_int: 0.999997748
p_ni: 0.000002252
Score: 0.557
Data Source: BioPlex,STRINGDB
IPO9
Tbio
Novelty: 0.03978028
p_int: 0.999996262
p_ni: 0.000003738
Score: 0.291
Data Source: BioPlex,STRINGDB
CRAMP1
Tdark
Novelty: 0.26519971
p_int: 0.999991664
p_ni: 0.000008332
p_wrong: 4e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  1904.67

PubMed score by year
PubTator Score  1155.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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