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Tbio
H2AFX
Histone H2AX

Protein Summary
Description
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating u ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375167
  • ENSP00000364310
  • ENSG00000188486
  • ENST00000530167
  • ENSP00000434024

Symbol
  • H2AX
  • H2AX
  • H2A.X
  • H2A/X
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
1
hub protein
1
phosphatase
1
transcription factor binding site profile
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1965.88   (req: < 5)
Gene RIFs: 277   (req: <= 3)
Antibodies: 1394   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1965.88   (req: >= 5)
Gene RIFs: 277   (req: > 3)
Antibodies: 1394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (689)
HIST1H2BD
Tbio
Novelty:  0.05094332
p_int:  1
Score:  0.97
Data Source:  BioPlex,STRINGDB
HIST1H2BO
Tdark
Novelty:  0.3427419
p_int:  1
Score:  0.96
Data Source:  BioPlex,STRINGDB
GON4L
Tbio
Novelty:  0.06166736
p_int:  0.999999856
p_ni:  1.44e-7
Data Source:  BioPlex
TONSL
Tbio
Novelty:  0.07220129
p_int:  0.999999552
p_ni:  4.48e-7
Score:  0.276
Data Source:  BioPlex,STRINGDB
HIST1H1C
Tbio
Novelty:  0.00415337
p_int:  0.999999496
p_ni:  5.04e-7
Score:  0.541
Data Source:  BioPlex,STRINGDB
PHF14
Tbio
Family:  Epigenetic
Novelty:  0.13279118
p_int:  0.999999118
p_ni:  8.81e-7
Score:  0.35
Data Source:  BioPlex,STRINGDB
MMS22L
Tbio
Novelty:  0.22570578
p_int:  0.999998215
p_ni:  0.000001785
Score:  0.241
Data Source:  BioPlex,STRINGDB
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.999997748
p_ni:  0.000002252
Score:  0.557
Data Source:  BioPlex,STRINGDB
IPO9
Tbio
Novelty:  0.03978028
p_int:  0.999996262
p_ni:  0.000003738
Score:  0.291
Data Source:  BioPlex,STRINGDB
CRAMP1
Tdark
Novelty:  0.26519971
p_int:  0.999991664
p_ni:  0.000008332
p_wrong:  4e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (97)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

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Find Similar Targets
Items per page:
1 – 5 of 83
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
2
2
94.6
platelet crit
2
2
2
93.5
lymphocyte count
3
3
3
88.2
body mass index
3
3
3
79.5
waist-hip ratio
2
2
2
75
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
2
94.6
platelet crit
2
93.5
lymphocyte count
3
88.2
body mass index
3
79.5
waist-hip ratio
2
75
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
H2A histone family member X
VGNC:12576
104001345
Mouse
MGI:102688
15270
Rat
RGD:1566119
500987
Dog
histone H2AX
489372
Cow
H2A histone family, member X
531733
Species
Name
OMA
EggNOG
Inparanoid
Chimp
H2A histone family member X
Mouse
Rat
Dog
histone H2AX
Cow
H2A histone family, member X
Publication Statistics
PubMed Score 1965.88
PubMed score by year
PubTator Score 1155.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title