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Tchem
NQO2
Ribosyldihydronicotinamide dehydrogenase [quinone]

Protein Summary
Description
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338130
  • ENSP00000337773
  • ENSG00000124588
  • ENST00000380430
  • ENSP00000369795
  • ENST00000380455
  • ENSP00000369822

Symbol
  • NMOR2
  • QR2
  • DHQV
  • DIA6
  • NMOR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.86
histone modification site profile
0.79
transcription factor binding site profile
0.79
disease perturbation
0.74
drug
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.36   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 473   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.36   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 473   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 168
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Active Ligands (168)
1 – 10 of 168
crenolanib
Rendered image for crenolanib
Cyc-116
Rendered image for Cyc-116
resveratrol
Rendered image for resveratrol
masitinib
Rendered image for masitinib
pacritinib
Rendered image for pacritinib
2-iodomelatonin
Rendered image for 2-iodomelatonin
CHEMBL300056
Rendered image for CHEMBL300056
CHEMBL52755
Rendered image for CHEMBL52755
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
21.5
platelet crit
1
1
1
8.8
heart function measurement
1
1
1
4.4
1
1
0
1.3
1.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
21.5
platelet crit
1
8.8
heart function measurement
1
4.4
0
1.3
1.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-ribosyldihydronicotinamide:quinone reductase 2
VGNC:9592
462395
Macaque
N-ribosyldihydronicotinamide:quinone reductase 2
707675
Mouse
MGI:104513
18105
Rat
RGD:1303320
291084
Dog
N-ribosyldihydronicotinamide:quinone reductase 2 [Source:HGNC Symbol;Acc:HGNC:7856]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-ribosyldihydronicotinamide:quinone reductase 2
Macaque
N-ribosyldihydronicotinamide:quinone reductase 2
Mouse
Rat
Dog
N-ribosyldihydronicotinamide:quinone reductase 2 [Source:HGNC Symbol;Acc:HGNC:7856]
Protein Structure (67 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P16083-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 67
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (38)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Metabolism
Phase I - Functionalization of compounds
Gene Ontology Terms (16)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Protein-Protein Interactions (22)
1 – 10 of 22
CRYZ
Tbio
Family:  Enzyme
Novelty:  0.00168463
Score:  0.73
Data Source:  STRINGDB
MTNR1A
Tclin
Family:  GPCR
Novelty:  0.01100617
Score:  0.669
Data Source:  STRINGDB
MTNR1B
Tclin
Family:  GPCR
Novelty:  0.00646326
Score:  0.647
Data Source:  STRINGDB
HMOX1
Tchem
Family:  Enzyme
Novelty:  0.00013981
Score:  0.571
Data Source:  STRINGDB
GCLC
Tchem
Family:  Enzyme
Novelty:  0.00217206
Score:  0.566
Data Source:  STRINGDB
NDUFA2
Tclin
Family:  Enzyme
Novelty:  0.02698508
Score:  0.565
Data Source:  STRINGDB
TXNDC17
Tbio
Novelty:  0.0142537
Score:  0.563
Data Source:  STRINGDB
NDUFB2
Tclin
Family:  Enzyme
Novelty:  0.05735054
Score:  0.54
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.534
Data Source:  STRINGDB
GCLM
Tbio
Family:  Enzyme
Novelty:  0.00395815
Score:  0.47
Data Source:  STRINGDB
Publication Statistics
PubMed Score  80.36

PubMed score by year
PubTator Score  121.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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