Tbio CD44 CD44 antigen

Protein Summary

Description

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P16070
• A5YRN9
• B6EAT9
• D3DR12
• D3DR13
• O95370
• P22511
• Q04858
• Q13419
• Q13957
• Q13958
• Q13959
• Q13960
• Q13961
• Q13967
• Q13968
• Q13980
• Q15861
• Q16064
• Q16065
• Q16066
• Q16208
• Q16522
• Q86T72
• Q86Z27
• Q8N694
• Q92493
• Q96J24
• Q9H5A5
• Q9UC28
• Q9UC29
• Q9UC30
• Q9UCB0
• Q9UJ36

Gene Name

• CD44

Ensembl ID

• ENST00000263398
• ENSP00000263398
• ENSG00000026508
• ENST00000278386
• ENSP00000278386
• ENST00000352818
• ENSP00000309732
• ENST00000415148
• ENSP00000389830
• ENST00000428726
• ENSP00000398632
• ENST00000433892
• ENSP00000392331
• ENST00000434472
• ENSP00000404447

Symbol

• LHR
• MDU2
• MDU3
• MIC4
• IN
• LHR
• MC56
• MDU2
• MDU3
• MIC4
• Pgp1
• CDW44
• CSPG8
• HCELL
• HUTCH-I
• ECMR-III

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
biological process	0.99
gene perturbation	0.94
microRNA	0.94
PubMedID	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9554.62   (req: < 5)

Gene RIFs: 1257   (req: <= 3)

Antibodies: 4804   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9554.62   (req: >= 5)

Gene RIFs: 1257   (req: > 3)

Antibodies: 4804   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0