Tbio TIMP2 Metalloproteinase inhibitor 2

Protein Summary

Description

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P16035
• Q16121
• Q93006
• Q9UDF7

Gene Name

• TIMP2

Ensembl ID

• ENST00000262768
• ENSP00000262768
• ENSG00000035862

Symbol

• DDC8
• CSC-21K

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
kinase perturbation	1
transcription factor perturbation	1
biological process	0.92
virus perturbation	0.88

Protein Classes

PANTHER Classes

Protein / ... / Protease Inhibitor / Metalloproteinase Inhibitor 2

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Metalloproteinase Inhibitor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1566.7   (req: < 5)

Gene RIFs: 432   (req: <= 3)

Antibodies: 1109   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1566.7   (req: >= 5)

Gene RIFs: 432   (req: > 3)

Antibodies: 1109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0