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Tbio
TIMP2
Metalloproteinase inhibitor 2

Protein Summary
Description
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262768
  • ENSP00000262768
  • ENSG00000035862

Symbol
  • DDC8
  • CSC-21K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
kinase perturbation
1
transcription factor perturbation
1
biological process
0.92
virus perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1449.14   (req: < 5)
Gene RIFs: 348   (req: <= 3)
Antibodies: 1109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1449.14   (req: >= 5)
Gene RIFs: 348   (req: > 3)
Antibodies: 1109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
4
81.3
2
2
2
76.7
HbA1c measurement
1
1
1
42.3
high density lipoprotein cholesterol measurement
1
1
1
21.5
gut microbiome measurement
1
1
3
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
81.3
2
76.7
HbA1c measurement
1
42.3
high density lipoprotein cholesterol measurement
1
21.5
gut microbiome measurement
3
21.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TIMP metallopeptidase inhibitor 2
VGNC:9705
743167
Mouse
MGI:98753
21858
Rat
RGD:61312
29543
Dog
TIMP metallopeptidase inhibitor 2
403633
Horse
TIMP metallopeptidase inhibitor 2
100034134
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TIMP metallopeptidase inhibitor 2
Mouse
Rat
Dog
TIMP metallopeptidase inhibitor 2
Horse
TIMP metallopeptidase inhibitor 2
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P16035-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Degradation of the extracellular matrix
Extracellular matrix organization
Immune System
Innate Immune System
Gene Ontology Terms (33)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (207)
1 – 10 of 207
FECH
Tchem
Family:  Enzyme
Novelty:  0.00282289
p_int:  0.999849703
p_ni:  0.000150296
p_wrong:  1e-9
Score:  0.534
Data Source:  BioPlex,STRINGDB
TIMP3
Tbio
Family:  Enzyme
Novelty:  0.00134742
p_int:  0.958960187
p_ni:  0.019922153
p_wrong:  0.02111766
Score:  0.762
Data Source:  BioPlex,STRINGDB
ZMYM6
Tdark
Novelty:  0.4933879
p_int:  0.958180069
p_ni:  0.04181993
p_wrong:  1e-9
Score:  0.21
Data Source:  BioPlex,STRINGDB
MMP2
Tchem
Family:  Enzyme
Novelty:  0.00012762
p_int:  0.786824469
p_ni:  0.213175531
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
MMP14
Tchem
Family:  Enzyme
Novelty:  0.00083836
p_int:  0.777079153
p_ni:  0.222920847
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
MMP9
Tchem
Family:  Enzyme
Novelty:  0.00008645
Score:  0.992
Data Source:  STRINGDB
MMP8
Tchem
Family:  Enzyme
Novelty:  0.00105859
Score:  0.985
Data Source:  STRINGDB
MMP16
Tchem
Family:  Enzyme
Novelty:  0.01028533
Score:  0.979
Data Source:  STRINGDB
MMP15
Tchem
Family:  Enzyme
Novelty:  0.01329346
Score:  0.978
Data Source:  STRINGDB
RECK
Tbio
Novelty:  0.00409224
Score:  0.975
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1449.14

PubMed score by year
PubTator Score  1304.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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