Tbio COX7C Cytochrome c oxidase subunit 7C, mitochondrial

Protein Summary

Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P15954
• Q6NR81

Gene Name

• COX7C

Ensembl ID

• ENST00000247655
• ENSP00000247655
• ENSG00000127184
• ENST00000509578
• ENSP00000425759

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
co-expressed gene	0.91
virus perturbation	0.85
kinase perturbation	0.76
transcription factor binding site profile	0.72

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxidase / Cytochrome C Oxidase Subunit 7c, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxidase / Cytochrome C Oxidase Subunit 7c, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.78   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 51   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.78   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0