Tchem MUC1 Mucin-1

Protein Summary

Description

The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity. This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• P15941
• A5YRV1
• A6ZID9
• A6ZIE0
• B1AVQ8
• B1AVR0
• B6ECA1
• E7ESE5
• E7EUG9
• P13931
• P15942
• P17626
• Q0VAP5
• Q0VAP6
• Q14128
• Q14876
• Q16437
• Q16442
• Q16615
• Q6S4Y3
• Q7Z547
• Q7Z548
• Q7Z550
• Q7Z552
• Q9BXA4
• Q9UE75
• Q9UE76
• Q9UQL1
• Q9Y4J2
• MUC-1

Gene Name

• MUC1

Ensembl ID

• ENST00000337604
• ENSP00000338983
• ENSG00000185499
• ENST00000342482
• ENSP00000342814
• ENST00000343256
• ENSP00000339690
• ENST00000368389
• ENSP00000357374
• ENST00000368390
• ENSP00000357375
• ENST00000368392
• ENSP00000357377
• ENST00000368393
• ENSP00000357378
• ENST00000368396
• ENSP00000357381
• ENST00000368398
• ENSP00000357383

Symbol

• PUM
• EMA
• MCD
• PEM
• PUM
• KL-6
• MAM6
• MCKD
• PEMT
• CD227
• H23AG
• MCKD1
• MUC-1
• ADMCKD
• ADMCKD1
• CA 15-3
• MUC-1/X
• MUC1/ZD
• MUC-1/SEC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
hub protein	0.94
transcription factor binding site profile	0.89
biological term	0.86
PubMedID	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5211.25   (req: < 5)

Gene RIFs: 857   (req: <= 3)

Antibodies: 4111   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5211.25   (req: >= 5)

Gene RIFs: 857   (req: > 3)

Antibodies: 4111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0