You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RPA2
Replication protein A 32 kDa subunit

Protein Summary
Description
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interacti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313433
  • ENSP00000363015
  • ENSG00000117748
  • ENST00000373909
  • ENSP00000363017
  • ENST00000373912
  • ENSP00000363021

Symbol
  • REPA2
  • RPA32
  • RPA34
  • REPA2
  • RPA32
  • RP-A p32
  • RP-A p34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
virus perturbation
1
co-expressed gene
0.93
histone modification site profile
0.91
protein complex
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.77   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 755   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.77   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 755   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
87.8
Moyamoya disease
1
1
0
1.6
76.5
myeloid white cell count
2
2
2
76
monocyte count
1
1
1
68.8
leukocyte count
2
2
2
65.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
87.8
Moyamoya disease
0
1.6
76.5
myeloid white cell count
2
76
monocyte count
1
68.8
leukocyte count
2
65.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
replication protein A2
VGNC:11017
456680
Macaque
replication protein A2
716612
Mouse
MGI:1339939
19891
Rat
RGD:619714
59102
Dog
replication protein A2
VGNC:45703
100856421
Species
Name
OMA
EggNOG
Inparanoid
Chimp
replication protein A2
Macaque
replication protein A2
Mouse
Rat
Dog
replication protein A2
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15927-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (84)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 70
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Base Excision Repair
Cell Cycle
Cell Cycle Checkpoints
Gene Ontology Terms (51)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (342)
1 – 10 of 342
XPC
Tbio
Novelty:  0.00775175
p_int:  0.99993215
p_ni:  0.00006785
Score:  0.984
Data Source:  BioPlex,STRINGDB
PARP2
Tclin
Family:  Enzyme
Novelty:  0.00545618
p_int:  0.99970935
p_ni:  0.000290645
p_wrong:  4e-9
Score:  0.946
Data Source:  BioPlex,STRINGDB
HMCES
Tbio
Family:  Enzyme
Novelty:  0.01229889
p_int:  0.999480085
p_ni:  0.000519915
Score:  0.241
Data Source:  BioPlex,STRINGDB
RPA3
Tbio
Novelty:  0.00887858
p_int:  0.999314025
p_ni:  0.000685975
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RPA1
Tchem
Novelty:  0.00212665
p_int:  0.99831629
p_ni:  0.00168371
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
LIG3
Tbio
Family:  Enzyme
Novelty:  0.00809038
p_int:  0.997587246
p_ni:  0.002412753
p_wrong:  1e-9
Score:  0.946
Data Source:  BioPlex,Reactome,STRINGDB
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
p_int:  0.99628091
p_ni:  0.00371909
Score:  0.768
Data Source:  BioPlex,STRINGDB
PARP1
Tclin
Family:  Enzyme
Novelty:  0.00033016
p_int:  0.975348638
p_ni:  0.024651362
Score:  0.987
Data Source:  BioPlex,STRINGDB
SSRP1
Tbio
Family:  TF
Novelty:  0.0143993
p_int:  0.942044296
p_ni:  0.057955704
Score:  0.844
Data Source:  BioPlex,STRINGDB
CETN2
Tbio
Novelty:  0.00641301
p_int:  0.827487321
p_ni:  0.172512665
p_wrong:  1.4e-8
Score:  0.948
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  102.77

PubMed score by year
PubTator Score  107.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: