Tbio DSP Desmoplakin

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Intermediate Filament / Intermediate Filament Binding Protein / Desmoplakin

DTO Classes

Protein / Cellular Structure / Intermediate Filament / Intermediate Filament Binding Protein / Desmoplakin

Protein Summary

Description

Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• P15924
• B2RTT2
• D7RX09
• O75993
• Q14189
• Q9UHN4
• DP

Gene Name

• DSP

Ensembl ID

• ENST00000379802
• ENSP00000369129
• ENSG00000096696
• ENST00000418664
• ENSP00000396591

Symbol

• DP
• DCWHKTA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
protein complex	1
gene perturbation	0.94
hub protein	0.88
transcription factor perturbation	0.8

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 515.73   (req: < 5)

Gene RIFs: 69   (req: <= 3)

Antibodies: 290   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 515.73   (req: >= 5)

Gene RIFs: 69   (req: > 3)

Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
idiopathic pulmonary fibrosis	EFO_0000768	2	1	0	1.4	93
interstitial lung disease	EFO_0004244	1	1	0	1.4	86.6
FEV/FEC ratio	EFO_0004713	1	1	1		64.8
chronic obstructive pulmonary disease	EFO_0000341	1	1	0	1.1	41.8
advanced glycosylation end product-specific receptor ligand measurement	EFO_0010762	1	1	1		35.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
idiopathic pulmonary fibrosis	EFO_0000768	0	1.4	93
interstitial lung disease	EFO_0004244	0	1.4	86.6
FEV/FEC ratio	EFO_0004713	1		64.8
chronic obstructive pulmonary disease	EFO_0000341	0	1.1	41.8
advanced glycosylation end product-specific receptor ligand measurement	EFO_0010762	1		35.8

Reset Zoom  Beta Count   Odds Ratio

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	desmoplakin	VGNC:2771	462420
Macaque	desmoplakin		694860
Mouse	desmoplakin	MGI:109611	109620
Rat	desmoplakin	RGD:1305794	306871
Dog	desmoplakin	VGNC:40110	488207

Species	Name	OMA	EggNOG	Inparanoid
Chimp	desmoplakin
Macaque	desmoplakin
Mouse	desmoplakin
Rat	desmoplakin
Dog	desmoplakin

Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (21)

Reactome (11)

KEGG (1)

PathwayCommons (3)

WikiPathways (6)

Apoptosis (R-HSA-109581)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Apoptosis	177 targets	R-HSA-109581
Reactome	Apoptotic cleavage of cell adhesion proteins	11 targets	R-HSA-351906
Reactome	Apoptotic cleavage of cellular proteins	38 targets	R-HSA-111465
Reactome	Apoptotic execution phase	52 targets	R-HSA-75153
Reactome	Developmental Biology	1055 targets	R-HSA-1266738

Name	Explore in Pharos	Explore in Source
Apoptosis	177 targets	R-HSA-109581
Apoptotic cleavage of cell adhesion proteins	11 targets	R-HSA-351906
Apoptotic cleavage of cellular proteins	38 targets	R-HSA-111465
Apoptotic execution phase	52 targets	R-HSA-75153
Developmental Biology	1055 targets	R-HSA-1266738

Gene Ontology Terms (38)

Functions (8)

Components (12)

Processes (18)

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Items per page:

10

1 – 8 of 8

GO Term	Evidence	Assigned by
protein binding, bridging	Inferred from Direct Assay (IDA)	UniProtKB
structural molecule activity	Inferred from Direct Assay (IDA)	UniProtKB
protein kinase C binding	Inferred from Physical Interaction (IPI)	BHF-UCL
scaffold protein binding	Inferred from Physical Interaction (IPI)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
structural constituent of cytoskeleton	Traceable Author Statement (TAS)	ProtInc
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	Inferred by Curator (IC)	BHF-UCL
cell adhesion molecule binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (122)

Explore Interacting Targets

1 – 10 of 122

• See Interactions on String-DB

C6orf141

Tdark

Novelty: 1.46022784

p_int: 0.952690678

p_ni: 0.047309322

Data Source: BioPlex

CCDC51

Tdark

Novelty: 1.19203634

p_int: 0.823710165

p_ni: 0.176289835

Score: 0.189

Data Source: BioPlex,STRINGDB

DTL

Tbio

Novelty: 0.01659105

p_int: 0.801716934

p_ni: 0.198283066

Data Source: BioPlex

CDK15

Tchem

Family: Kinase

Novelty: 0.3870338

p_int: 0.773158232

p_ni: 0.226841768

Score: 0.194

Data Source: BioPlex,STRINGDB

SYCE1

Tbio

Novelty: 0.05038876

p_int: 0.754581204

p_ni: 0.245418796

Data Source: BioPlex

PKP2

Tbio

Novelty: 0.00493803

Score: 0.996

Data Source: STRINGDB

DSC2

Tbio

Novelty: 0.00642576

Score: 0.995

Data Source: STRINGDB

DSG2

Tbio

Novelty: 0.00524156

Score: 0.994

Data Source: STRINGDB

JUP

Tbio

Novelty: 0.0081803

Score: 0.993

Data Source: STRINGDB

PKP3

Tbio

Novelty: 0.0269462

Score: 0.992

Data Source: STRINGDB

Publication Statistics

PubMed Score  515.73

PubMed score by year

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PubTator Score  87.24

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Cardiomyopathy
Cell junction
Cell membrane
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation

GWAS Trait Find Similar Targets

advanced glycosylation end product-specific receptor ligand measurement
chronic obstructive pulmonary disease
FEV/FEC ratio
idiopathic pulmonary fibrosis
interstitial lung disease
vital capacity

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
growth/size/body region phenotype
integument phenotype
mortality/aging
muscle phenotype
nervous system phenotype