Protein Summary
Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
- ENST00000379802
- ENSP00000369129
- ENSG00000096696
- ENST00000418664
- ENSP00000396591
- DP
- DCWHKTA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
protein complex | 1 | ||
gene perturbation | 0.94 | ||
hub protein | 0.88 | ||
transcription factor perturbation | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 529.05 (req: < 5)
Gene RIFs: 69 (req: <= 3)
Antibodies: 290 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 529.05 (req: >= 5)
Gene RIFs: 69 (req: > 3)
Antibodies: 290 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (122)
CCDC51
Novelty: 1.19203634
p_int: 0.823710165
p_ni: 0.176289835
Score: 0.189
Data Source: BioPlex,STRINGDB
CDK15
Family: Kinase
Novelty: 0.3870338
p_int: 0.773158232
p_ni: 0.226841768
Score: 0.194
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (21)
Reactome (11)
KEGG (1)
PathwayCommons (3)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cell adhesion proteins | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | Developmental Biology | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Apoptosis | ||||
Apoptotic cleavage of cell adhesion proteins | ||||
Apoptotic cleavage of cellular proteins | ||||
Apoptotic execution phase | ||||
Developmental Biology | ||||
Viral Interactions (0)
Gene Ontology Terms (38)
Functions (8)
Components (12)
Processes (18)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred by Curator (IC) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 1 | 0 | 1.4 | 79.8 | |||||
FEV/FEC ratio | 1 | 1 | 1 | 75.2 | |||||
1 | 1 | 0 | 1.4 | 71.9 | |||||
advanced glycosylation end product-specific receptor ligand measurement | 1 | 1 | 1 | 40.7 | |||||
1 | 1 | 0 | 1.1 | 30.2 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.4 | 79.8 | |||||
FEV/FEC ratio | 1 | 75.2 | |||||
0 | 1.4 | 71.9 | |||||
advanced glycosylation end product-specific receptor ligand measurement | 1 | 40.7 | |||||
0 | 1.1 | 30.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | desmoplakin | VGNC:2771 | 462420 | |||||
Macaque | desmoplakin | 694860 | ||||||
Mouse | MGI:109611 | 109620 | ||||||
Rat | RGD:1305794 | 306871 | ||||||
Dog | desmoplakin | VGNC:40110 | 488207 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | desmoplakin | |||||
Macaque | desmoplakin | |||||
Mouse | ||||||
Rat | ||||||
Dog | desmoplakin | |||||
Publication Statistics
PubMed Score 529.05
PubMed score by year
PubTator Score 87.24
PubTator score by year
Related Publications
Text Mined References (134)
GeneRif Annotations (69)
Items per page:
0 of 0
PMID | Year | Title |
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