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Tbio
DSP
Desmoplakin

Protein Summary
Description
Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379802
  • ENSP00000369129
  • ENSG00000096696
  • ENST00000418664
  • ENSP00000396591

Symbol
  • DP
  • DCWHKTA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
1
gene perturbation
0.94
hub protein
0.88
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 529.05   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 529.05   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.4
79.8
FEV/FEC ratio
1
1
1
75.2
1
1
0
1.4
71.9
advanced glycosylation end product-specific receptor ligand measurement
1
1
1
40.7
1
1
0
1.1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
79.8
FEV/FEC ratio
1
75.2
0
1.4
71.9
advanced glycosylation end product-specific receptor ligand measurement
1
40.7
0
1.1
30.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
desmoplakin
VGNC:2771
462420
Macaque
desmoplakin
694860
Mouse
MGI:109611
109620
Rat
RGD:1305794
306871
Dog
desmoplakin
VGNC:40110
488207
Species
Name
OMA
EggNOG
Inparanoid
Chimp
desmoplakin
Macaque
desmoplakin
Mouse
Rat
Dog
desmoplakin
Protein Structure (4 Structures, 9 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cell adhesion proteins
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cell adhesion proteins
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Developmental Biology
Gene Ontology Terms (38)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred by Curator (IC)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (122)
1 – 10 of 122
C6orf141
Tdark
Novelty:  1.46022784
p_int:  0.952690678
p_ni:  0.047309322
Data Source:  BioPlex
CCDC51
Tdark
Novelty:  1.19203634
p_int:  0.823710165
p_ni:  0.176289835
Score:  0.189
Data Source:  BioPlex,STRINGDB
DTL
Tbio
Novelty:  0.01659105
p_int:  0.801716934
p_ni:  0.198283066
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.773158232
p_ni:  0.226841768
Score:  0.194
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.754581204
p_ni:  0.245418796
Data Source:  BioPlex
PKP2
Tbio
Novelty:  0.00493803
Score:  0.996
Data Source:  STRINGDB
DSC2
Tbio
Novelty:  0.00642576
Score:  0.995
Data Source:  STRINGDB
DSG2
Tbio
Novelty:  0.00524156
Score:  0.994
Data Source:  STRINGDB
JUP
Tbio
Novelty:  0.0081803
Score:  0.993
Data Source:  STRINGDB
PKP3
Tbio
Novelty:  0.0269462
Score:  0.992
Data Source:  STRINGDB
Publication Statistics
PubMed Score  529.05

PubMed score by year
PubTator Score  87.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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