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Tbio
TCF3
Transcription factor E2-alpha

Protein Summary
Description
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region. This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or dimin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262965
  • ENSP00000262965
  • ENSG00000071564
  • ENST00000395423
  • ENSP00000378813
  • ENST00000588136
  • ENSP00000468487
  • ENST00000611869
  • ENSP00000480564

Symbol
  • BHLHB21
  • E2A
  • ITF1
  • E2A
  • E47
  • p75
  • AGM8
  • ITF1
  • VDIR
  • TCF-3
  • bHLHb21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.98
disease perturbation
0.97
PubMedID
0.97
hub protein
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 817.48   (req: < 5)
Gene RIFs: 94   (req: <= 3)
Antibodies: 533   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 817.48   (req: >= 5)
Gene RIFs: 94   (req: > 3)
Antibodies: 533   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
52.5
1
1
1
37.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
52.5
1
37.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor 3
VGNC:13532
468650
Macaque
transcription factor 3
721325
Mouse
MGI:98510
21423
Rat
RGD:620914
171046
Dog
transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:11633]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor 3
Macaque
transcription factor 3
Mouse
Rat
Dog
transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:11633]
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15923-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Myogenesis
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Myogenesis
RNA Polymerase II Transcription
Gene Ontology Terms (38)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (226)
1 – 10 of 226
FERD3L
Tbio
Family: TF
Novelty: 0.06797434
p_int: 0.999999987
p_ni: 1.3e-8
Score: 0.813
Data Source: BioPlex,STRINGDB
NEUROD1
Tbio
Family: TF
Novelty: 0.00188624
p_int: 0.999999985
p_ni: 1.5e-8
Score: 0.975
Data Source: BioPlex,STRINGDB
ID2
Tbio
Family: TF
Novelty: 0.00256364
p_int: 0.999999936
p_ni: 6.4e-8
Score: 0.881
Data Source: BioPlex,STRINGDB
NEUROG3
Tbio
Family: TF
Novelty: 0.00341077
p_int: 0.999999935
p_ni: 6.5e-8
Score: 0.561
Data Source: BioPlex,STRINGDB
MYF6
Tbio
Family: TF
Novelty: 0.00509046
p_int: 0.99999991
p_ni: 9e-8
Score: 0.979
Data Source: BioPlex,Reactome,STRINGDB
HAND2
Tbio
Family: TF
Novelty: 0.00478924
p_int: 0.999999907
p_ni: 9.3e-8
Score: 0.644
Data Source: BioPlex,STRINGDB
NHLH2
Tbio
Family: TF
Novelty: 0.04744703
p_int: 0.999998322
p_ni: 0.000001678
Score: 0.464
Data Source: BioPlex,STRINGDB
TWIST2
Tbio
Family: TF
Novelty: 0.00748285
p_int: 0.999997523
p_ni: 0.000002477
Score: 0.645
Data Source: BioPlex,STRINGDB
FKBP9
Tbio
Family: Enzyme
Novelty: 0.16472204
p_int: 0.99962585
p_ni: 0.00037415
Score: 0.173
Data Source: BioPlex,STRINGDB
TCF4
Tbio
Family: TF
Novelty: 0.0019718
p_int: 0.996685679
p_ni: 0.003314301
p_wrong: 2e-8
Score: 0.983
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  817.48

PubMed score by year
PubTator Score  402.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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