ST6GAL1
Beta-galactoside alpha-2,6-sialyltransferase 1
Protein Summary
Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
- ENST00000169298
- ENSP00000169298
- ENSG00000073849
- ENST00000448044
- ENSP00000389337
- ENST00000457772
- ENSP00000412221
- SIAT1
- ST6N
- SIAT1
- ST6GalI
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.96 | ||
kinase perturbation | 0.95 | ||
cellular component | 0.87 | ||
transcription factor binding site profile | 0.87 | ||
disease perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 486.18 (req: < 5)
Gene RIFs: 92 (req: <= 3)
Antibodies: 524 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 486.18 (req: >= 5)
Gene RIFs: 92 (req: > 3)
Antibodies: 524 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 15
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0