Tbio TCF4 Transcription factor 4

Protein Summary

Description

Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• P15884
• B3KT62
• B3KUC0
• B4DT37
• B4DUG3
• B7Z5M6
• B7Z6Y1
• G0LNT9
• G0LNU0
• G0LNU1
• G0LNU2
• G0LNU4
• G0LNU5
• G0LNU8
• G0LNU9
• G0LNV0
• G0LNV1
• G0LNV2
• H3BPQ1
• Q08AP2
• Q08AP3
• Q15439
• Q15440
• Q15441
• TCF-4

Gene Name

• TCF4

Ensembl ID

• ENST00000354452
• ENSP00000346440
• ENSG00000196628
• ENST00000356073
• ENSP00000348374
• ENST00000457482
• ENSP00000409447
• ENST00000537578
• ENSP00000440731
• ENST00000537856
• ENSP00000439827
• ENST00000540999
• ENSP00000445202
• ENST00000543082
• ENSP00000439656
• ENST00000544241
• ENSP00000441562
• ENST00000561831
• ENSP00000457765
• ENST00000561992
• ENSP00000455179
• ENST00000564228
• ENSP00000455261
• ENST00000564999
• ENSP00000457649
• ENST00000565018
• ENSP00000455984
• ENST00000566279
• ENSP00000456125
• ENST00000566286
• ENSP00000455418
• ENST00000567880
• ENSP00000454366
• ENST00000568673
• ENSP00000455135
• ENST00000570177
• ENSP00000454647
• ENST00000570287
• ENSP00000455763
• ENST00000616053
• ENSP00000478549
• ENST00000626584
• ENSP00000486072
• ENST00000629387
• ENSP00000486670
• ENST00000636400
• ENSP00000490006

Symbol

• BHLHB19
• ITF2
• SEF2
• E2-2
• ITF2
• PTHS
• SEF2
• FECD3
• ITF-2
• SEF-2
• TCF-4
• SEF2-1
• SEF2-1A
• SEF2-1B
• SEF2-1D
• bHLHb19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
kinase perturbation	0.98
disease perturbation	0.97
transcription factor perturbation	0.97
small molecule perturbation	0.82

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Transcription Factor 4

Protein / Nucleic Acid Binding / Transcription Factor 4

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Transcription Factor 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.74   (req: < 5)

Gene RIFs: 173   (req: <= 3)

Antibodies: 349   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.74   (req: >= 5)

Gene RIFs: 173   (req: > 3)

Antibodies: 349   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0