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Tbio
RPS2
40S ribosomal protein S2

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343262
  • ENSP00000341885
  • ENSG00000140988

Symbol
  • RPS4
  • S2
  • LLREP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
microRNA
1
protein domain
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.47   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.47   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (641)
PDCD2L
Tbio
Novelty:  0.33193498
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.807
Data Source:  BioPlex,STRINGDB
PRMT3
Tchem
Family:  Epigenetic
Novelty:  0.03433797
p_int:  0.999999938
p_ni:  6.2e-8
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
ZNF277
Tbio
Novelty:  0.21739031
p_int:  0.999999863
p_ni:  1.37e-7
Score:  0.275
Data Source:  BioPlex,STRINGDB
YBX2
Tbio
Family:  TF
Novelty:  0.01540247
p_int:  0.999994062
p_ni:  0.000005938
Score:  0.608
Data Source:  BioPlex,STRINGDB
PDCD2
Tbio
Novelty:  0.05054811
p_int:  0.999604622
p_ni:  0.000395378
Score:  0.557
Data Source:  BioPlex,STRINGDB
COPRS
Tbio
Novelty:  0.03545787
p_int:  0.999538471
p_ni:  0.000461301
p_wrong:  2.28e-7
Score:  0.155
Data Source:  BioPlex,STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
p_int:  0.999101303
p_ni:  0.000898696
Score:  0.999
Data Source:  BioPlex,STRINGDB
NAT10
Tbio
Family:  Enzyme
Novelty:  0.02453679
p_int:  0.997507267
p_ni:  0.002492733
Score:  0.187
Data Source:  BioPlex,STRINGDB
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.996984645
p_ni:  0.003015355
Score:  0.441
Data Source:  BioPlex,STRINGDB
DHX57
Tdark
Family:  Enzyme
Novelty:  0.8244078
p_int:  0.996681934
p_ni:  0.003318066
Score:  0.304
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (45)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 42
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Chromatin modifying enzymes
Chromatin organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
3
3
92
glomerular filtration rate
2
2
2
78.7
2
3
0
1.1
77.8
hemoglobin measurement
2
1
2
75.6
red blood cell density measurement
1
1
1
71.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
3
92
glomerular filtration rate
2
78.7
0
1.1
77.8
hemoglobin measurement
2
75.6
red blood cell density measurement
1
71.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:105110
16898
Rat
RGD:619887
83789
Rat
Dog
ribosomal protein S2
102155201
Horse
ribosomal protein S2
VGNC:51227
100065572
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Rat
Dog
ribosomal protein S2
Horse
ribosomal protein S2
Publication Statistics
PubMed Score 237.47
PubMed score by year
PubTator Score 273.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title