You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ARSB
Arylsulfatase B

Protein Summary
Description
Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264914
  • ENSP00000264914
  • ENSG00000113273
  • ENST00000396151
  • ENSP00000379455

Symbol
  • ASB
  • G4S
  • MPS6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
biological process
0.84
small molecule perturbation
0.83
cellular component
0.8
transcription factor binding site profile
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.8   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.8   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
64.2
monocyte percentage of leukocytes
1
1
1
17.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
64.2
monocyte percentage of leukocytes
1
17.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arylsulfatase B
VGNC:11821
737316
Macaque
arylsulfatase B
709136
Mouse
MGI:88075
11881
Rat
RGD:2158
25227
Dog
arylsulfatase B
VGNC:38143
610364
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arylsulfatase B
Macaque
arylsulfatase B
Mouse
Rat
Dog
arylsulfatase B
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15848-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
CS/DS degradation (R-HSA-2024101)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
CS/DS degradation
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Name
Explore in Pharos
Explore in Source
CS/DS degradation
Chondroitin sulfate/dermatan sulfate metabolism
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Protein-Protein Interactions (144)
1 – 10 of 144
ERP29
Tbio
Novelty: 0.0132632
p_int: 0.999677985
p_ni: 0.000321886
p_wrong: 1.3e-7
Score: 0.273
Data Source: BioPlex,STRINGDB
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.999433313
p_ni: 0.000566407
p_wrong: 2.8e-7
Data Source: BioPlex
PTPRK
Tbio
Family: Enzyme
Novelty: 0.03149943
p_int: 0.999390122
p_ni: 0.000602194
p_wrong: 0.000007684
Score: 0.161
Data Source: BioPlex,STRINGDB
INSL5
Tbio
Novelty: 0.04351334
p_int: 0.998911531
p_ni: 0.001088434
p_wrong: 3.5e-8
Data Source: BioPlex
NAAA
Tchem
Family: Enzyme
Novelty: 0.00368876
p_int: 0.994824816
p_ni: 0.005006623
p_wrong: 0.000168561
Score: 0.271
Data Source: BioPlex,STRINGDB
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
p_int: 0.994295415
p_ni: 0.005680963
p_wrong: 0.000023621
Data Source: BioPlex
LCN6
Tbio
Novelty: 0.11406686
p_int: 0.992782279
p_ni: 0.007027482
p_wrong: 0.000190239
Data Source: BioPlex
RLN1
Tbio
Novelty: 0.03992636
p_int: 0.992150279
p_ni: 0.007251418
p_wrong: 0.000598303
Data Source: BioPlex
AVP
Tbio
Novelty: 0.00016475
p_int: 0.991530233
p_ni: 0.008415469
p_wrong: 0.000054297
Score: 0.181
Data Source: BioPlex,STRINGDB
SIAE
Tbio
Family: Enzyme
Novelty: 0.01138067
p_int: 0.97764758
p_ni: 0.022267184
p_wrong: 0.000085236
Score: 0.622
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  104.80

PubMed score by year
PubTator Score  401.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: