Tbio HIVEP1 Zinc finger protein 40

Protein Summary

Description

This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif, GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular genes. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• P15822
• B2RTU3
• Q14122
• Q5MPB1
• Q5VW60

Gene Name

• HIVEP1

Ensembl ID

• ENST00000379388
• ENSP00000368698
• ENSG00000095951

Symbol

• ZNF40
• GAAP
• ZAS1
• CIRIP
• MBP-1
• ZNF40
• CRYBP1
• ZNF40A
• PRDII-BF1
• Schnurri-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
transcription factor binding site profile	0.9
transcription factor	0.89
disease perturbation	0.74
cell line	0.62

Protein Classes

DTO Classes

Zinc Finger Protein 407 / Zinc Finger Protein 404

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.25   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 32   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.25   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0