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Tbio
HIVEP1
Zinc finger protein 40

Protein Classes
Protein Summary
Description
This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis. This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379388
  • ENSP00000368698
  • ENSG00000095951

Symbol
  • ZNF40
  • GAAP
  • ZAS1
  • CIRIP
  • MBP-1
  • ZNF40
  • CRYBP1
  • ZNF40A
  • PRDII-BF1
  • Schnurri-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor binding site profile
0.9
transcription factor
0.89
disease perturbation
0.74
cell line
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.97   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.97   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
1
6
91
monocyte count
1
1
1
63.3
neutrophil count
2
1
2
47.5
lymphocyte percentage of leukocytes
1
1
1
35.8
neutrophil percentage of leukocytes
1
1
1
32.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
91
monocyte count
1
63.3
neutrophil count
2
47.5
lymphocyte percentage of leukocytes
1
35.8
neutrophil percentage of leukocytes
1
32.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
human immunodeficiency virus type I enhancer binding protein 1
471857
Mouse
MGI:96100
110521
Rat
RGD:727847
117140
Dog
human immunodeficiency virus type I enhancer binding protein 1
488221
Horse
human immunodeficiency virus type I enhancer binding protein 1
100064320
Species
Name
OMA
EggNOG
Inparanoid
Chimp
human immunodeficiency virus type I enhancer binding protein 1
Mouse
Rat
Dog
human immunodeficiency virus type I enhancer binding protein 1
Horse
human immunodeficiency virus type I enhancer binding protein 1
Protein Structure (3 Structures, 8 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (36)
1 – 10 of 36
BTRC
Tbio
Novelty: 0.00293475
p_int: 1
Score: 0.56
Data Source: BioPlex,STRINGDB
FBXW11
Tbio
Novelty: 0.0715377
p_int: 0.999992121
p_ni: 0.000007762
p_wrong: 1.17e-7
Score: 0.687
Data Source: BioPlex,STRINGDB
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.999952804
p_ni: 0.000047166
p_wrong: 3e-8
Data Source: BioPlex
UTP4
Tbio
Novelty: 0.06989008
Score: 0.814
Data Source: STRINGDB
BMP2
Tbio
Novelty: 0.00016974
Score: 0.704
Data Source: STRINGDB
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
Score: 0.669
Data Source: STRINGDB
PCDH8
Tbio
Novelty: 0.01006306
Score: 0.644
Data Source: STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.627
Data Source: STRINGDB
CLIC4
Tbio
Family: IC
Novelty: 0.01088335
Score: 0.62
Data Source: STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
Score: 0.602
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.97

PubMed score by year
PubTator Score  20.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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