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Tbio
IGLL1
Immunoglobulin lambda-like polypeptide 1

Protein Summary
Description
Critical for B-cell development. The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249053
  • ENSP00000249053
  • ENSG00000128322
  • ENST00000330377
  • ENSP00000329312

Symbol
  • IGL1
  • IGO
  • 14.1
  • AGM2
  • IGL1
  • IGL5
  • IGLL
  • IGVPB
  • CD179b
  • VPREB2
  • IGLJ14.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.64
virus perturbation
0.59
protein domain
0.58
cell line
0.53
cell type or tissue
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 325.2   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 325.2   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
IGLL5
Tbio
Novelty:  0.00459259
p_int:  0.999969936
p_ni:  1.7e-8
p_wrong:  0.000030047
Score:  0.932
Data Source:  BioPlex,STRINGDB
VPREB1
Tbio
Novelty:  0.00742085
Score:  0.998
Data Source:  Reactome,STRINGDB
VPREB3
Tbio
Novelty:  0.13999956
Score:  0.973
Data Source:  Reactome,STRINGDB
IGLC1
Tdark
Novelty:  0.00459259
Score:  0.932
Data Source:  STRINGDB
IGHV3-11
Tdark
Novelty:  0.09180836
Score:  0.903
Data Source:  STRINGDB
JCHAIN
Tbio
Novelty:  0.00172454
Score:  0.878
Data Source:  STRINGDB
CD79B
Tclin
Novelty:  0.00227414
Score:  0.836
Data Source:  STRINGDB
CD79A
Tbio
Novelty:  0.00118942
Score:  0.828
Data Source:  STRINGDB
IKZF1
Tbio
Family:  TF
Novelty:  0.0016117
Score:  0.698
Data Source:  STRINGDB
MZB1
Tbio
Novelty:  0.04147497
Score:  0.671
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96529
16136
Rat
RGD:2321140
100360919
Dog
immunoglobulin lambda-like polypeptide 5
100687054
Pig
immunoglobulin lambda-like polypeptide 5
100523213
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
immunoglobulin lambda-like polypeptide 5
Pig
immunoglobulin lambda-like polypeptide 5
Publication Statistics
PubMed Score 325.20
PubMed score by year
PubTator Score 79.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title