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Tclin
VEGFA
Vascular endothelial growth factor A

Protein Summary
Description
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372077
  • ENSP00000361148
  • ENSG00000112715
  • ENST00000457104
  • ENSP00000409911
  • ENST00000518689
  • ENSP00000430829
  • ENST00000518824
  • ENSP00000430002
  • ENST00000520948
  • ENSP00000428321
  • ENST00000523125
  • ENSP00000429008
  • ENST00000523873
  • ENSP00000430479
  • ENST00000523950
  • ENSP00000429643
  • ENST00000611736
  • ENSP00000478570
  • ENST00000615393
  • ENSP00000478034
  • ENST00000617771
  • ENSP00000484284
  • ENST00000621747
  • ENSP00000483241
  • ENST00000640482
  • ENSP00000492800
  • ENST00000640499
  • ENSP00000492413
  • ENST00000640653
  • ENSP00000492199

Symbol
  • VEGF
  • VPF
  • VEGF
  • MVCD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
disease
1
small molecule perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34645.72   (req: < 5)
Gene RIFs: 4064   (req: <= 3)
Antibodies: 2331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34645.72   (req: >= 5)
Gene RIFs: 4064   (req: > 3)
Antibodies: 2331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 121
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6