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Tbio
GNS
N-acetylglucosamine-6-sulfatase

Protein Classes
Protein Summary
Description
The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258145
  • ENSP00000258145
  • ENSG00000135677
  • ENST00000542058
  • ENSP00000444819

Symbol
  • G6S
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
histone modification site profile
0.87
protein domain
0.85
kinase perturbation
0.84
cellular component
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.75   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.75   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucosamine (N-acetyl)-6-sulfatase
VGNC:13094
467054
Macaque
glucosamine (N-acetyl)-6-sulfatase
717500
Mouse
MGI:1922862
75612
Rat
RGD:1305877
299825
Dog
glucosamine (N-acetyl)-6-sulfatase
VGNC:54150
474429
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucosamine (N-acetyl)-6-sulfatase
Macaque
glucosamine (N-acetyl)-6-sulfatase
Mouse
Rat
Dog
glucosamine (N-acetyl)-6-sulfatase
Pathways (20)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Glycosaminoglycan metabolism
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Glycosaminoglycan metabolism
Immune System
Protein-Protein Interactions (155)
1 – 10 of 155
ENGASE
Tchem
Family: Enzyme
Novelty: 0.00920032
p_int: 0.999931915
p_ni: 2.1e-7
p_wrong: 0.000067874
Score: 0.517
Data Source: BioPlex,STRINGDB
SUMF1
Tbio
Family: Enzyme
Novelty: 0.00954537
p_int: 0.998899008
p_ni: 0.001094779
p_wrong: 0.000006213
Score: 0.759
Data Source: BioPlex,STRINGDB
FKBP14
Tbio
Family: Enzyme
Novelty: 0.02742616
p_int: 0.985456525
p_ni: 0.014440862
p_wrong: 0.000102613
Score: 0.174
Data Source: BioPlex,STRINGDB
SULF2
Tbio
Family: Enzyme
Novelty: 0.01536228
p_int: 0.966982547
p_ni: 0.033012042
p_wrong: 0.000005411
Score: 0.259
Data Source: BioPlex,STRINGDB
CLPX
Tbio
Family: Enzyme
Novelty: 0.00254331
p_int: 0.936902936
p_ni: 0.063097064
Score: 0.228
Data Source: BioPlex,STRINGDB
CUL1
Tbio
Novelty: 0.00244476
p_int: 0.889884823
p_ni: 0.110115177
Score: 0.175
Data Source: BioPlex,STRINGDB
CAPN2
Tchem
Novelty: 0.00431673
p_int: 0.88607723
p_ni: 0.11392277
Score: 0.221
Data Source: BioPlex,STRINGDB
GUSB
Tchem
Family: Enzyme
Novelty: 0.00053974
Score: 0.947
Data Source: STRINGDB
GALNS
Tbio
Family: Enzyme
Novelty: 0.00510529
Score: 0.941
Data Source: STRINGDB
GRN
Tbio
Novelty: 0.00096395
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.75

PubMed score by year
PubTator Score  26.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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