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Tchem
NQO1
NAD(P)H dehydrogenase [quinone] 1

Protein Summary
Description
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been char ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320623
  • ENSP00000319788
  • ENSG00000181019
  • ENST00000379046
  • ENSP00000368334
  • ENST00000379047
  • ENSP00000368335

Symbol
  • DIA4
  • NMOR1
  • DTD
  • QR1
  • DHQU
  • DIA4
  • NMOR1
  • NMORI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
transcription factor perturbation
1
biological term
0.99
PubMedID
0.96
kinase perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1460.26   (req: < 5)
Gene RIFs: 335   (req: <= 3)
Antibodies: 724   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1460.26   (req: >= 5)
Gene RIFs: 335   (req: > 3)
Antibodies: 724   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 57
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dicoumarol
chemical structure image
Protein Data Bank (16)
1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of polyamines
Reactome
Regulation of ornithine decarboxylase (ODC)
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Metabolism of polyamines
Regulation of ornithine decarboxylase (ODC)
Gene Ontology Terms (28)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (176)
1 – 10 of 176
FAM24B
Tdark
p_int: 0.919597467
p_ni: 0.080392601
p_wrong: 0.000009931
Data Source: BioPlex
HMOX1
Tchem
Family: Enzyme
Novelty: 0.00016148
Score: 0.952
Data Source: STRINGDB
NFE2L2
Tchem
Family: TF
Novelty: 0.00057265
Score: 0.941
Data Source: STRINGDB
VKORC1
Tclin
Family: Enzyme
Novelty: 0.00170777
Score: 0.939
Data Source: STRINGDB
ADK
Tchem
Family: Kinase
Novelty: 0.00282266
Score: 0.935
Data Source: STRINGDB
CRYZ
Tbio
Family: Enzyme
Novelty: 0.0019263
Score: 0.929
Data Source: STRINGDB
ODC1
Tclin
Family: Enzyme
Novelty: 0.00041795
Score: 0.928
Data Source: Reactome,STRINGDB
GGCX
Tclin
Family: Enzyme
Novelty: 0.01163709
Score: 0.919
Data Source: STRINGDB
TP63
Tbio
Family: TF
Novelty: 0.00114506
Score: 0.902
Data Source: STRINGDB
KEAP1
Tclin
Novelty: 0.00083765
Score: 0.901
Data Source: STRINGDB
Publication Statistics
PubMed Score  1460.26

PubMed score by year
PubTator Score  1311.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPA
1-70
ESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRS
70-140
KKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKK
140-210
RLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
210-274
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK