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Tchem
NQO1
NAD(P)H dehydrogenase [quinone] 1

Protein Summary
Description
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been char ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320623
  • ENSP00000319788
  • ENSG00000181019
  • ENST00000379046
  • ENSP00000368334
  • ENST00000379047
  • ENSP00000368335

Symbol
  • DIA4
  • NMOR1
  • DTD
  • QR1
  • DHQU
  • DIA4
  • NMOR1
  • NMORI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
transcription factor perturbation
1
biological term
0.99
PubMedID
0.96
kinase perturbation
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1842.48   (req: < 5)
Gene RIFs: 335   (req: <= 3)
Antibodies: 724   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1842.48   (req: >= 5)
Gene RIFs: 335   (req: > 3)
Antibodies: 724   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 57
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dicoumarol
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
65.1
triglyceride measurement
1
1
1
52.8
risk-taking behaviour
1
1
1
32.3
alcohol consumption measurement
1
1
2
15.3
HMG CoA reductase inhibitor use measurement
1
1
1
9.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
65.1
triglyceride measurement
1
52.8
risk-taking behaviour
1
32.3
alcohol consumption measurement
2
15.3
HMG CoA reductase inhibitor use measurement
1
9.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NAD(P)H quinone dehydrogenase 1
VGNC:9094
468012
Macaque
NAD(P)H quinone dehydrogenase 1
705635
Mouse
MGI:103187
18104
Rat
RGD:2503
24314
Dog
NAD(P)H quinone dehydrogenase 1
VGNC:53429
610935
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NAD(P)H quinone dehydrogenase 1
Macaque
NAD(P)H quinone dehydrogenase 1
Mouse
Rat
Dog
NAD(P)H quinone dehydrogenase 1
Protein Structure (16 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15559-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of polyamines
Reactome
Regulation of ornithine decarboxylase (ODC)
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Metabolism of polyamines
Regulation of ornithine decarboxylase (ODC)
Gene Ontology Terms (28)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (176)
1 – 10 of 176
FAM24B
Tdark
Novelty: 1.04675689
p_int: 0.919597467
p_ni: 0.080392601
p_wrong: 0.000009931
Data Source: BioPlex
HMOX1
Tchem
Family: Enzyme
Novelty: 0.00013981
Score: 0.952
Data Source: STRINGDB
NFE2L2
Tchem
Family: TF
Novelty: 0.00043828
Score: 0.941
Data Source: STRINGDB
VKORC1
Tclin
Family: Enzyme
Novelty: 0.00135838
Score: 0.939
Data Source: STRINGDB
ADK
Tchem
Family: Kinase
Novelty: 0.00196435
Score: 0.935
Data Source: STRINGDB
CRYZ
Tbio
Family: Enzyme
Novelty: 0.00168463
Score: 0.929
Data Source: STRINGDB
ODC1
Tclin
Family: Enzyme
Novelty: 0.00037968
Score: 0.928
Data Source: Reactome,STRINGDB
GGCX
Tclin
Family: Enzyme
Novelty: 0.00819484
Score: 0.919
Data Source: STRINGDB
TP63
Tbio
Family: TF
Novelty: 0.00336108
Score: 0.902
Data Source: STRINGDB
KEAP1
Tclin
Novelty: 0.00062812
Score: 0.901
Data Source: STRINGDB
Publication Statistics
PubMed Score  1842.48

PubMed score by year
PubTator Score  1311.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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