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Tclin
CYP11B1
Cytochrome P450 11B1, mitochondrial

Protein Summary
Description
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292427
  • ENSP00000292427
  • ENSG00000160882
  • ENST00000517471
  • ENSP00000428043

Symbol
  • S11BH
  • FHI
  • CPN1
  • CYP11B
  • P450C11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.93
drug
0.7
pathway
0.67
disease
0.65
biological term
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 491.28   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 491.28   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 579
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Active Ligands (579)
1 – 10 of 579
CHEMBL295698
chemical structure image
CHEMBL1172882
chemical structure image
CHEMBL14192
chemical structure image
CHEMBL1173260
chemical structure image
CHEMBL305220
chemical structure image
CHEMBL307160
chemical structure image
CHEMBL78322
chemical structure image
CHEMBL362968,CHEMBL460178
chemical structure image
CHEMBL2333326
chemical structure image
CHEMBL2333336
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
79.9
androstenedione measurement
1
2
2
62
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
79.9
androstenedione measurement
2
62
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88583
110115
Dog
cytochrome P450, family 11, subfamily B, polypeptide 2
482071
Opossum
cytochrome P450 11B1, mitochondrial
100032885
Anole lizard
cytochrome P450 11B, mitochondrial
100560890
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
cytochrome P450, family 11, subfamily B, polypeptide 2
Opossum
cytochrome P450 11B1, mitochondrial
Anole lizard
cytochrome P450 11B, mitochondrial
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P15538-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (235)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
Reactome
Disease
Reactome
Diseases of metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytochrome P450 - arranged by substrate type
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
Disease
Diseases of metabolism
Protein-Protein Interactions (53)
1 – 10 of 53
HSD3B2
Tclin
Family: Enzyme
Novelty: 0.00711552
Score: 0.979
Data Source: STRINGDB
HSD3B1
Tchem
Family: Enzyme
Novelty: 0.0019271
Score: 0.974
Data Source: STRINGDB
HSD17B6
Tbio
Family: Enzyme
Novelty: 0.01428594
Score: 0.972
Data Source: STRINGDB
HSD11B2
Tchem
Family: Enzyme
Novelty: 0.00182237
Score: 0.967
Data Source: STRINGDB
HSD17B3
Tchem
Family: Enzyme
Novelty: 0.00666322
Score: 0.956
Data Source: STRINGDB
HSD11B1
Tclin
Family: Enzyme
Novelty: 0.00105097
Score: 0.954
Data Source: STRINGDB
CYP17A1
Tclin
Family: Enzyme
Novelty: 0.00065091
Score: 0.95
Data Source: STRINGDB
CYP21A2
Tchem
Family: Enzyme
Novelty: 0.00110959
Score: 0.948
Data Source: STRINGDB
CYP11B2
Tchem
Novelty: 0.00128614
Score: 0.945
Data Source: STRINGDB
HSD17B2
Tchem
Family: Enzyme
Novelty: 0.00960865
Score: 0.942
Data Source: STRINGDB
Publication Statistics
PubMed Score  491.28

PubMed score by year
PubTator Score  387.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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