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Tbio
NME1
Nucleoside diphosphate kinase A

Protein Summary
Description
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000013034
  • ENSP00000013034
  • ENSG00000239672
  • ENST00000336097
  • ENSP00000337060
  • ENST00000393196
  • ENSP00000376892

Symbol
  • NDPKA
  • NM23
  • NB
  • AWD
  • NBS
  • GAAD
  • NDKA
  • NM23
  • NDPKA
  • NDPK-A
  • NM23-H1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
transcription factor binding site profile
0.98
disease perturbation
0.96
interacting protein
0.96
biological process
0.89


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1050.42   (req: < 5)
Gene RIFs: 232   (req: <= 3)
Antibodies: 1169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1050.42   (req: >= 5)
Gene RIFs: 232   (req: > 3)
Antibodies: 1169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NME/NM23 nucleoside diphosphate kinase 1
100533953
Mouse
MGI:97355
18102
Rat
RGD:70497
191575
Opossum
NME/NM23 nucleoside diphosphate kinase 1
100012868
Xenopus
NME/NM23 nucleoside diphosphate kinase 2
XB-GENE-923233
448725
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NME/NM23 nucleoside diphosphate kinase 1
Mouse
Rat
Opossum
NME/NM23 nucleoside diphosphate kinase 1
Xenopus
NME/NM23 nucleoside diphosphate kinase 2
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15531-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Gene Ontology Terms (44)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (272)
1 – 10 of 272
NME3
Tbio
Family: Kinase
Novelty: 0.05947052
p_int: 0.917833933
p_ni: 0.082166067
Score: 0.939
Data Source: BioPlex,Reactome,STRINGDB
SET
Tbio
Novelty: 0.01012327
Score: 0.986
Data Source: STRINGDB
TIAM1
Tbio
Novelty: 0.00431726
Score: 0.977
Data Source: STRINGDB
APEX1
Tchem
Family: Enzyme
Novelty: 0.00037532
Score: 0.974
Data Source: STRINGDB
ANP32A
Tbio
Novelty: 0.00567095
Score: 0.973
Data Source: STRINGDB
GZMA
Tbio
Family: Enzyme
Novelty: 0.00322362
Score: 0.973
Data Source: STRINGDB
DNM2
Tchem
Novelty: 0.00265965
Score: 0.964
Data Source: STRINGDB
DNM1
Tbio
Novelty: 0.00319082
Score: 0.958
Data Source: STRINGDB
NME4
Tbio
Family: Kinase
Novelty: 0.03735196
Score: 0.952
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.952
Data Source: STRINGDB
Publication Statistics
PubMed Score  1050.42

PubMed score by year
PubTator Score  1019.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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