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Tbio
CD46
Membrane cofactor protein

Protein Summary
Description
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. (Microbial infection) Acts as a receptor for cultured Measles virus. (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6. (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and S ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322875
  • ENSP00000313875
  • ENSG00000117335
  • ENST00000322918
  • ENSP00000314664
  • ENST00000354848
  • ENSP00000346912
  • ENST00000357714
  • ENSP00000350346
  • ENST00000358170
  • ENSP00000350893
  • ENST00000360212
  • ENSP00000353342
  • ENST00000367041
  • ENSP00000356008
  • ENST00000367042
  • ENSP00000356009
  • ENST00000367047
  • ENSP00000356014
  • ENST00000480003
  • ENSP00000418471

Symbol
  • MCP
  • MIC10
  • MCP
  • TLX
  • AHUS2
  • MIC10
  • TRA2.10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
cell type or tissue
0.82
gene perturbation
0.74
microRNA
0.74
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1052.88   (req: < 5)
Gene RIFs: 138   (req: <= 3)
Antibodies: 1193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1052.88   (req: >= 5)
Gene RIFs: 138   (req: > 3)
Antibodies: 1193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate
1
1
1
84.6
myeloid white cell count
1
1
1
80.1
leukocyte count
1
1
1
46.2
Febrile seizure (within the age range of 3 months to 6 years)
1
1
0
1.5
45.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate
1
84.6
myeloid white cell count
1
80.1
leukocyte count
1
46.2
Febrile seizure (within the age range of 3 months to 6 years)
0
1.5
45.8
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD46 molecule
VGNC:10558
469663
Macaque
CD46 molecule
714082
Mouse
MGI:1203290
17221
Rat
RGD:3061
29333
Rat
RGD:1559810
365577
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD46 molecule
Macaque
CD46 molecule
Mouse
Rat
Rat
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15529-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (50)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of Complement cascade
Name
Explore in Pharos
Explore in Source
Complement cascade
Immune System
Innate Immune System
Regulation of Complement cascade
Gene Ontology Terms (25)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (95)
1 – 10 of 95
TRIM16L
Tdark
Novelty: 1.32785612
p_int: 0.90942121
p_ni: 0.000011135
p_wrong: 0.090567655
Score: 0.359
Data Source: BioPlex,STRINGDB
C3
Tbio
Novelty: 0.00019115
Score: 0.998
Data Source: Reactome,STRINGDB
C4B
Tbio
Novelty: 0.00068357
Score: 0.992
Data Source: Reactome,STRINGDB
C4A
Tbio
Novelty: 0.00062793
Score: 0.988
Data Source: Reactome,STRINGDB
CFI
Tbio
Novelty: 0.00271423
Score: 0.977
Data Source: Reactome,STRINGDB
C2
Tbio
Novelty: 0.00974862
Score: 0.945
Data Source: STRINGDB
CFB
Tchem
Novelty: 0.00102672
Score: 0.929
Data Source: STRINGDB
CR1
Tbio
Novelty: 0.00157449
Score: 0.921
Data Source: STRINGDB
NECTIN4
Tclin
Novelty: 0.00694563
Score: 0.897
Data Source: STRINGDB
CD59
Tbio
Novelty: 0.0008352
Score: 0.89
Data Source: STRINGDB
Publication Statistics
PubMed Score  1052.88

PubMed score by year
PubTator Score  1515.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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