You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CD46
Membrane cofactor protein

Protein Summary
Description
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. (Microbial infection) Acts as a receptor for cultured Measles virus. (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6. (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and S ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322875
  • ENSP00000313875
  • ENSG00000117335
  • ENST00000322918
  • ENSP00000314664
  • ENST00000354848
  • ENSP00000346912
  • ENST00000357714
  • ENSP00000350346
  • ENST00000358170
  • ENSP00000350893
  • ENST00000360212
  • ENSP00000353342
  • ENST00000367041
  • ENSP00000356008
  • ENST00000367042
  • ENSP00000356009
  • ENST00000367047
  • ENSP00000356014
  • ENST00000480003
  • ENSP00000418471

Symbol
  • MCP
  • MIC10
  • MCP
  • TLX
  • AHUS2
  • MIC10
  • TRA2.10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
cell type or tissue
0.82
gene perturbation
0.74
microRNA
0.74
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1145.6   (req: < 5)
Gene RIFs: 155   (req: <= 3)
Antibodies: 1193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1145.6   (req: >= 5)
Gene RIFs: 155   (req: > 3)
Antibodies: 1193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0