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Tbio
CD46
Membrane cofactor protein

Protein Summary
Description
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. (Microbial infection) Acts as a receptor for cultured Measles virus. (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6. (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and S ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322875
  • ENSP00000313875
  • ENSG00000117335
  • ENST00000322918
  • ENSP00000314664
  • ENST00000354848
  • ENSP00000346912
  • ENST00000357714
  • ENSP00000350346
  • ENST00000358170
  • ENSP00000350893
  • ENST00000360212
  • ENSP00000353342
  • ENST00000367041
  • ENSP00000356008
  • ENST00000367042
  • ENSP00000356009
  • ENST00000367047
  • ENSP00000356014
  • ENST00000480003
  • ENSP00000418471

Symbol
  • MCP
  • MIC10
  • MCP
  • TLX
  • AHUS2
  • MIC10
  • TRA2.10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
cell type or tissue
0.82
gene perturbation
0.74
microRNA
0.74
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 888.18   (req: < 5)
Gene RIFs: 138   (req: <= 3)
Antibodies: 1193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 888.18   (req: >= 5)
Gene RIFs: 138   (req: > 3)
Antibodies: 1193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (50)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of Complement cascade
Name
Explore in Pharos
Explore in Source
Complement cascade
Immune System
Innate Immune System
Regulation of Complement cascade
Gene Ontology Terms (25)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (95)
1 – 10 of 95
TRIM16L
Tdark
Novelty: 5.18518519
p_int: 0.90942121
p_ni: 0.000011135
p_wrong: 0.090567655
Score: 0.359
Data Source: BioPlex,STRINGDB
C3
Tbio
Novelty: 0.00025052
Score: 0.998
Data Source: Reactome,STRINGDB
C4B
Tbio
Novelty: 0.00094534
Score: 0.992
Data Source: Reactome,STRINGDB
C4A
Tbio
Novelty: 0.00075974
Score: 0.988
Data Source: Reactome,STRINGDB
CFI
Tbio
Novelty: 0.00194994
Score: 0.977
Data Source: Reactome,STRINGDB
C2
Tbio
Novelty: 0.01346942
Score: 0.945
Data Source: STRINGDB
CFB
Tchem
Novelty: 0.00128742
Score: 0.929
Data Source: STRINGDB
CR1
Tbio
Novelty: 0.00116665
Score: 0.921
Data Source: STRINGDB
NECTIN4
Tclin
Novelty: 0.00776653
Score: 0.897
Data Source: STRINGDB
CD59
Tbio
Novelty: 0.00056697
Score: 0.89
Data Source: STRINGDB
Publication Statistics
PubMed Score  888.18

PubMed score by year
PubTator Score  1515.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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