Tbio CD46 Membrane cofactor protein

Protein Summary

Description

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells. (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. (Microbial infection) Acts as a receptor for cultured Measles virus. (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6. (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006). The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• P15529
• A0T1T0
• A0T1T1
• A0T1T2
• Q15429
• Q53GV9
• Q5HY94
• Q5VWS6
• Q5VWS7
• Q5VWS8
• Q5VWS9
• Q5VWT0
• Q5VWT1
• Q5VWT2
• Q6N0A1
• Q7Z3R5
• Q9NNW2
• Q9NNW3
• Q9NNW4
• Q9UCJ4

Gene Name

• CD46

Ensembl ID

• ENST00000322875
• ENSP00000313875
• ENSG00000117335
• ENST00000322918
• ENSP00000314664
• ENST00000354848
• ENSP00000346912
• ENST00000357714
• ENSP00000350346
• ENST00000358170
• ENSP00000350893
• ENST00000360212
• ENSP00000353342
• ENST00000367041
• ENSP00000356008
• ENST00000367042
• ENSP00000356009
• ENST00000367047
• ENSP00000356014
• ENST00000480003
• ENSP00000418471

Symbol

• MCP
• MIC10
• MCP
• TLX
• AHUS2
• MIC10
• TRA2.10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.91
cell type or tissue	0.82
gene perturbation	0.74
microRNA	0.74
transcription factor perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1145.6   (req: < 5)

Gene RIFs: 162   (req: <= 3)

Antibodies: 1193   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1145.6   (req: >= 5)

Gene RIFs: 162   (req: > 3)

Antibodies: 1193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0