Tbio HTN3 Histatin-3

Protein Summary

Description

Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9. This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• P15516
• Q16243
• Q502Z1

Gene Name

• HTN3

Ensembl ID

• ENST00000526767
• ENSP00000437158
• ENSG00000205649
• ENST00000530128
• ENSP00000432561
• ENST00000634949
• ENSP00000489290
• ENSG00000282967
• ENST00000635585
• ENSP00000489520

Symbol

• HIS2
• PB
• HIS2
• HTN2
• HTN5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.46
cell line	0.46
disease	0.45
chemical	0.44
tissue	0.44

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.97   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 10   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.97   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 10   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0