You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HTN3
Histatin-3

Protein Summary
Description
Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9. This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000526767
  • ENSP00000437158
  • ENSG00000205649
  • ENST00000530128
  • ENSP00000432561
  • ENST00000634949
  • ENSP00000489290
  • ENSG00000282967
  • ENST00000635585
  • ENSP00000489520

Symbol
  • HIS2
  • PB
  • HIS2
  • HTN2
  • HTN5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.46
cell line
0.46
disease
0.45
chemical
0.44
tissue
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.86   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 10   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.86   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 10   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (65)
1 – 10 of 65
ZNF91
Tbio
Family:  TF
Novelty:  0.05629584
Score:  0.904
Data Source:  STRINGDB
HTN1
Tbio
Novelty:  0.00870349
Score:  0.903
Data Source:  STRINGDB
STATH
Tbio
Novelty:  0.00486778
Score:  0.825
Data Source:  STRINGDB
STRC
Tbio
Novelty:  0.01587212
Score:  0.741
Data Source:  STRINGDB
CATSPER2
Tchem
Family:  IC
Novelty:  0.03701031
Score:  0.741
Data Source:  STRINGDB
ZNF154
Tbio
Family:  TF
Novelty:  0.1287115
Score:  0.652
Data Source:  STRINGDB
ZNF138
Tdark
Family:  TF
Novelty:  3.68758686
Score:  0.644
Data Source:  STRINGDB
ZNF135
Tbio
Family:  TF
Novelty:  0.00312804
Score:  0.644
Data Source:  STRINGDB
ZNF131
Tbio
Family:  TF
Novelty:  0.18894578
Score:  0.644
Data Source:  STRINGDB
ZNF142
Tdark
Family:  TF
Novelty:  0.46019293
Score:  0.644
Data Source:  STRINGDB
Pathways (4)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histatin 3
VGNC:616
100610105
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histatin 3
Publication Statistics
PubMed Score 124.86
PubMed score by year
PubTator Score 294.33
PubTator score by year