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Tbio
AREG
Amphiregulin

Protein Summary
Description
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts. The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395748
  • ENSP00000379097
  • ENSG00000109321

Symbol
  • AREGB
  • SDGF
  • AR
  • SDGF
  • AREGB
  • CRDGF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.96
virus perturbation
0.92
biological term
0.87
PubMedID
0.81
biological process
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 606.43   (req: < 5)
Gene RIFs: 136   (req: <= 3)
Antibodies: 528   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 606.43   (req: >= 5)
Gene RIFs: 136   (req: > 3)
Antibodies: 528   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
27.3
hair color
1
1
0
1.1
9.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
27.3
hair color
0
1.1
9.3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15514-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (60)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 42
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cargo concentration in the ER
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Gene Ontology Terms (31)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (181)
1 – 10 of 181
ADCY9
Tbio
Family: Enzyme
Novelty: 0.00744116
p_int: 0.999981853
p_ni: 0.000018145
p_wrong: 2e-9
Score: 0.233
Data Source: BioPlex,STRINGDB
ICAM1
Tchem
Novelty: 0.00009746
p_int: 0.99816591
p_ni: 0.001447618
p_wrong: 0.000386472
Score: 0.81
Data Source: BioPlex,STRINGDB
SNX11
Tdark
Novelty: 0.21586113
p_int: 0.809090616
p_ni: 0.113615016
p_wrong: 0.077294369
Score: 0.187
Data Source: BioPlex,STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.994
Data Source: STRINGDB
ERBB3
Tclin
Family: Kinase
Novelty: 0.000868
Score: 0.981
Data Source: STRINGDB
ERBB2
Tclin
Family: Kinase
Novelty: 0.00003761
Score: 0.978
Data Source: STRINGDB
TGFA
Tbio
Novelty: 0.00216159
Score: 0.978
Data Source: STRINGDB
EREG
Tbio
Novelty: 0.00371897
Score: 0.929
Data Source: STRINGDB
CNIH1
Tbio
Novelty: 0.0932447
Score: 0.913
Data Source: Reactome,STRINGDB
EGF
Tbio
Novelty: 0.00010809
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score  606.43

PubMed score by year
PubTator Score  306.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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