Protein Summary
Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deleti ...more
- ENST00000252034
- ENSP00000252034
- ENSG00000049540
- ENST00000320399
- ENSP00000313565
- ENST00000357036
- ENSP00000349540
- ENST00000358929
- ENSP00000351807
- ENST00000380553
- ENSP00000369926
- ENST00000380562
- ENSP00000369936
- ENST00000380575
- ENSP00000369949
- ENST00000380576
- ENSP00000369950
- ENST00000380584
- ENSP00000369958
- ENST00000429192
- ENSP00000391129
- WS
- WBS
- SVAS
- ADCL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.97 | ||
disease | 0.8 | ||
phenotype | 0.69 | ||
cell line | 0.66 | ||
PubMedID | 0.65 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3500.06 (req: < 5)
Gene RIFs: 178 (req: <= 3)
Antibodies: 390 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3500.06 (req: >= 5)
Gene RIFs: 178 (req: > 3)
Antibodies: 390 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
pulse pressure measurement | 1 | 1 | 1 | 4.2 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
pulse pressure measurement | 1 | 4.2 | |||||
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Rat | RGD:67394 | 25043 | ||||||
Dog | elastin | VGNC:54018 | 607775 | |||||
Horse | elastin | VGNC:51126 | 102150882 | |||||
Cow | elastin | 280781 | ||||||
Opossum | elastin [Source:HGNC Symbol;Acc:HGNC:3327] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Rat | ||||||
Dog | elastin | |||||
Horse | elastin | |||||
Cow | elastin | |||||
Opossum | elastin [Source:HGNC Symbol;Acc:HGNC:3327] | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (109)
Reactome (2)
KEGG (1)
PathwayCommons (1)
WikiPathways (105)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 2 of 2
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Elastic fibre formation | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Elastic fibre formation | ||||
Extracellular matrix organization | ||||
Gene Ontology Terms (13)
Functions (2)
Components (4)
Processes (7)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (225)
1 – 10 of 225
LOX
Family: Enzyme
Novelty: 0.000273
Score: 0.994
Data Source: Reactome,STRINGDB
FBLN5
Novelty: 0.00599598
Score: 0.993
Data Source: Reactome,STRINGDB
LOXL1
Family: Enzyme
Novelty: 0.00479897
Score: 0.985
Data Source: Reactome,STRINGDB
MFAP2
Novelty: 0.01599653
Score: 0.983
Data Source: Reactome,STRINGDB
LOXL2
Family: Enzyme
Novelty: 0.00599536
Score: 0.966
Data Source: STRINGDB
LOXL3
Family: Enzyme
Novelty: 0.03895154
Score: 0.958
Data Source: STRINGDB
LOXL4
Family: Enzyme
Novelty: 0.02390071
Score: 0.956
Data Source: STRINGDB
MFAP5
Novelty: 0.01839035
Score: 0.948
Data Source: Reactome,STRINGDB
FBN1
Novelty: 0.00074957
Score: 0.905
Data Source: Reactome,STRINGDB
EFEMP2
Novelty: 0.01635649
Score: 0.898
Data Source: STRINGDB
Publication Statistics
PubMed Score 3500.06
PubMed score by year
PubTator Score 5554.2
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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