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Tbio
ELN
Elastin

Protein Summary
Description
Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deleti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252034
  • ENSP00000252034
  • ENSG00000049540
  • ENST00000320399
  • ENSP00000313565
  • ENST00000357036
  • ENSP00000349540
  • ENST00000358929
  • ENSP00000351807
  • ENST00000380553
  • ENSP00000369926
  • ENST00000380562
  • ENSP00000369936
  • ENST00000380575
  • ENSP00000369949
  • ENST00000380576
  • ENSP00000369950
  • ENST00000380584
  • ENSP00000369958
  • ENST00000429192
  • ENSP00000391129

Symbol
  • WS
  • WBS
  • SVAS
  • ADCL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.97
disease
0.8
phenotype
0.69
cell line
0.66
PubMedID
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3560.93   (req: < 5)
Gene RIFs: 178   (req: <= 3)
Antibodies: 390   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3560.93   (req: >= 5)
Gene RIFs: 178   (req: > 3)
Antibodies: 390   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (225)
LOX
Tchem
Family:  Enzyme
Novelty:  0.000273
Score:  0.994
Data Source:  Reactome,STRINGDB
FBLN5
Tbio
Novelty:  0.00599598
Score:  0.993
Data Source:  Reactome,STRINGDB
LOXL1
Tbio
Family:  Enzyme
Novelty:  0.00479897
Score:  0.985
Data Source:  Reactome,STRINGDB
MFAP2
Tbio
Novelty:  0.01599653
Score:  0.983
Data Source:  Reactome,STRINGDB
LOXL2
Tchem
Family:  Enzyme
Novelty:  0.00599536
Score:  0.966
Data Source:  STRINGDB
LOXL3
Tchem
Family:  Enzyme
Novelty:  0.03895154
Score:  0.958
Data Source:  STRINGDB
LOXL4
Tchem
Family:  Enzyme
Novelty:  0.02390071
Score:  0.956
Data Source:  STRINGDB
MFAP5
Tbio
Novelty:  0.01839035
Score:  0.948
Data Source:  Reactome,STRINGDB
FBN1
Tbio
Novelty:  0.00074957
Score:  0.905
Data Source:  Reactome,STRINGDB
EFEMP2
Tbio
Novelty:  0.01635649
Score:  0.898
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (109)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
45.2
2
2
0
1.6
32.8
pulse pressure measurement
1
1
1
8.9
1
1
0
1.5
7.1
1
1
0
1.5
7.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
45.2
0
1.6
32.8
pulse pressure measurement
1
8.9
0
1.5
7.1
0
1.5
7.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Rat
RGD:67394
25043
Dog
elastin
VGNC:54018
607775
Horse
elastin
VGNC:51126
102150882
Cow
elastin
280781
Opossum
elastin [Source:HGNC Symbol;Acc:HGNC:3327]
Species
Name
OMA
EggNOG
Inparanoid
Rat
Dog
elastin
Horse
elastin
Cow
elastin
Opossum
elastin [Source:HGNC Symbol;Acc:HGNC:3327]
Publication Statistics
PubMed Score 3560.93
PubMed score by year
PubTator Score 5554.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title