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Tchem
VAV1
Proto-oncogene vav

Protein Summary
Description
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000596764
  • ENSP00000469450
  • ENSG00000141968
  • ENST00000602142
  • ENSP00000472929

Symbol
  • VAV
  • VAV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
protein domain
1
kinase perturbation
0.96
disease perturbation
0.93
biological process
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 578.97   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 701   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 578.97   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 701   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
3
0
1.4
96.9
mean platelet volume
3
3
5
96
2
2
0
1.6
94.1
atrophic macular degeneration
2
2
0
1.8
94.1
lymphocyte count
2
2
3
77.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
96.9
mean platelet volume
5
96
0
1.6
94.1
atrophic macular degeneration
0
1.8
94.1
lymphocyte count
3
77.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vav guanine nucleotide exchange factor 1
VGNC:2419
455647
Macaque
vav guanine nucleotide exchange factor 1
100424246
Mouse
MGI:98923
22324
Rat
RGD:3951
25156
Dog
vav guanine nucleotide exchange factor 1
VGNC:48236
485016
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vav guanine nucleotide exchange factor 1
Macaque
vav guanine nucleotide exchange factor 1
Mouse
Rat
Dog
vav guanine nucleotide exchange factor 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15498-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (99)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 45
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
CD28 co-stimulation
Reactome
CD28 dependent Vav1 pathway
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
CD28 co-stimulation
CD28 dependent Vav1 pathway
Cell death signalling via NRAGE, NRIF and NADE
Gene Ontology Terms (32)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
CAFA
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (368)
1 – 10 of 368
KLK7
Tchem
Family:  Enzyme
Novelty:  0.00757766
p_int:  0.999848797
p_ni:  0.000151012
p_wrong:  1.92e-7
Data Source:  BioPlex
PLBD1
Tdark
Family:  Enzyme
Novelty:  0.27639575
p_int:  0.999614801
p_ni:  0.000385197
p_wrong:  2e-9
Score:  0.206
Data Source:  BioPlex,STRINGDB
NUB1
Tbio
Novelty:  0.00736082
p_int:  0.999136087
p_ni:  0.000001684
p_wrong:  0.000862228
Score:  0.277
Data Source:  BioPlex,STRINGDB
SPECC1L
Tbio
Novelty:  0.06116909
p_int:  0.995856446
p_ni:  0.004143554
Data Source:  BioPlex
SERPINA12
Tbio
Novelty:  0.00549132
p_int:  0.994227541
p_ni:  0.005772438
p_wrong:  2.1e-8
Data Source:  BioPlex
APLP2
Tbio
Novelty:  0.0082936
p_int:  0.98734576
p_ni:  0.01265424
Score:  0.534
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.983147033
p_ni:  0.016852967
Data Source:  BioPlex
SDR9C7
Tbio
Family:  Enzyme
Novelty:  0.01618496
p_int:  0.980589837
p_ni:  0.019206545
p_wrong:  0.000203619
Data Source:  BioPlex
SERPINB2
Tbio
Novelty:  0.00204345
p_int:  0.96497537
p_ni:  0.030302546
p_wrong:  0.004722084
Score:  0.18
Data Source:  BioPlex,STRINGDB
APBB2
Tbio
Novelty:  0.06546724
p_int:  0.958721181
p_ni:  0.04102177
p_wrong:  0.00025705
Data Source:  BioPlex
Publication Statistics
PubMed Score  578.97

PubMed score by year
PubTator Score  353.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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