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Tchem
HPGD
15-hydroxyprostaglandin dehydrogenase [NAD(+)]

Protein Summary
Description
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells. This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296521
  • ENSP00000296521
  • ENSG00000164120
  • ENST00000296522
  • ENSP00000296522
  • ENST00000422112
  • ENSP00000398720
  • ENST00000510901
  • ENSP00000422418
  • ENST00000541923
  • ENSP00000438017
  • ENST00000542498
  • ENSP00000443644

Symbol
  • PGDH1
  • SDR36C1
  • PGDH
  • PGDH1
  • PHOAR1
  • 15-PGDH
  • SDR36C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
molecular function
0.95
transcription factor perturbation
0.91
PubMedID
0.9
small molecule perturbation
0.83


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 324.91   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 469   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 324.91   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 469   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 177
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
15-hydroxyprostaglandin dehydrogenase
VGNC:48903
461613
Macaque
15-hydroxyprostaglandin dehydrogenase
697864
Mouse
MGI:108085
15446
Rat
RGD:620087
79242
Dog
15-hydroxyprostaglandin dehydrogenase
VGNC:49605
486073
Species
Name
OMA
EggNOG
Inparanoid
Chimp
15-hydroxyprostaglandin dehydrogenase
Macaque
15-hydroxyprostaglandin dehydrogenase
Mouse
Rat
Dog
15-hydroxyprostaglandin dehydrogenase
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biosynthesis of D-series resolvins
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of E-series 18(S)-resolvins
Reactome
Biosynthesis of EPA-derived SPMs
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biosynthesis of D-series resolvins
Biosynthesis of DHA-derived SPMs
Biosynthesis of E-series 18(S)-resolvins
Biosynthesis of EPA-derived SPMs
Gene Ontology Terms (28)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (50)
1 – 10 of 50
PTGS2
Tclin
Family: Enzyme
Novelty: 0.00007089
Score: 0.803
Data Source: STRINGDB
HSD11B2
Tchem
Family: Enzyme
Novelty: 0.00182237
Score: 0.751
Data Source: STRINGDB
SLCO2A1
Tchem
Family: Transporter
Novelty: 0.00133475
Score: 0.738
Data Source: STRINGDB
PTGES
Tchem
Family: Enzyme
Novelty: 0.00146096
Score: 0.709
Data Source: STRINGDB
RAB11FIP1
Tbio
Novelty: 0.0445306
Score: 0.645
Data Source: STRINGDB
VMP1
Tbio
Novelty: 0.00997613
Score: 0.635
Data Source: STRINGDB
PTGES2
Tchem
Family: Enzyme
Novelty: 0.01415352
Score: 0.615
Data Source: STRINGDB
PTGER4
Tclin
Family: GPCR
Novelty: 0.0008127
Score: 0.595
Data Source: STRINGDB
ZADH2
Tdark
Family: Enzyme
Novelty: 0.11800677
Score: 0.579
Data Source: STRINGDB
IL6
Tclin
Novelty: 0.00001819
Score: 0.577
Data Source: STRINGDB
Publication Statistics
PubMed Score  324.91

PubMed score by year
PubTator Score  169.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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