You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FOSL2
Fos-related antigen 2

Protein Summary
Description
Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264716
  • ENSP00000264716
  • ENSG00000075426
  • ENST00000379619
  • ENSP00000368939

Symbol
  • FRA2
  • FRA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
1
kinase perturbation
0.99
transcription factor binding site profile
0.97
PubMedID
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.33   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 519   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.33   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 519   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
53.1
Eczema
1
1
0
1
53.1
sex hormone-binding globulin measurement
2
1
2
35.5
2
1
2
8.4
age at onset
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
53.1
Eczema
0
1
53.1
sex hormone-binding globulin measurement
2
35.5
2
8.4
age at onset
1
6.5
Gene Ontology Terms (13)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (101)
1 – 10 of 101
JUNB
Tbio
Family: TF
Novelty: 0.00841656
p_int: 1
Score: 0.997
Data Source: BioPlex,STRINGDB
JUND
Tbio
Family: TF
Novelty: 0.00277701
p_int: 0.99999998
p_ni: 2e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
ATF7
Tbio
Family: TF
Novelty: 0.01470313
p_int: 0.999999977
p_ni: 2.3e-8
Score: 0.79
Data Source: BioPlex,STRINGDB
ATF2
Tbio
Family: TF
Novelty: 0.00457832
p_int: 0.999999945
p_ni: 5.5e-8
Score: 0.611
Data Source: BioPlex,STRINGDB
CREB5
Tbio
Family: TF
Novelty: 0.03857106
p_int: 0.999999838
p_ni: 1.61e-7
Score: 0.748
Data Source: BioPlex,STRINGDB
BACH2
Tbio
Family: TF
Novelty: 0.00932069
p_int: 0.999998013
p_ni: 0.000001987
Score: 0.414
Data Source: BioPlex,STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
p_int: 0.999995346
p_ni: 0.000004654
Score: 0.996
Data Source: BioPlex,STRINGDB
NBEA
Tbio
Novelty: 0.02583687
p_int: 0.999988165
p_ni: 0.000011835
Score: 0.187
Data Source: BioPlex,STRINGDB
IRF2BPL
Tdark
Novelty: 0.05458595
p_int: 0.999975566
p_ni: 0.000024434
Score: 0.678
Data Source: BioPlex,STRINGDB
IRF2BP1
Tdark
Novelty: 0.29719488
p_int: 0.999916957
p_ni: 0.000083043
Score: 0.672
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  235.33

PubMed score by year
PubTator Score  85.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: