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Tbio
FOSL1
Fos-related antigen 1

Protein Summary
Description
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312562
  • ENSP00000310170
  • ENSG00000175592
  • ENST00000448083
  • ENSP00000393302

Symbol
  • FRA1
  • FRA
  • FRA1
  • fra-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
gene perturbation
1
biological process
0.95
small molecule perturbation
0.93
chemical
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.11   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 373   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.11   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 373   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
2
3
89.9
self reported educational attainment
1
1
1
82.3
eosinophil percentage of leukocytes
2
2
2
69.6
sum of eosinophil and basophil counts
1
1
1
51.5
1
1
0
1.1
24.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
89.9
self reported educational attainment
1
82.3
eosinophil percentage of leukocytes
2
69.6
sum of eosinophil and basophil counts
1
51.5
0
1.1
24.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FOS like 1, AP-1 transcription factor subunit
VGNC:6556
745919
Macaque
FOS like 1, AP-1 transcription factor subunit
106993191
Mouse
MGI:107179
14283
Rat
RGD:2627
25445
Dog
FOS like 1, AP-1 transcription factor subunit
VGNC:40942
483724
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FOS like 1, AP-1 transcription factor subunit
Macaque
FOS like 1, AP-1 transcription factor subunit
Mouse
Rat
Dog
FOS like 1, AP-1 transcription factor subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P15407-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (23)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Human T-cell leukemia virus 1 infection
KEGG
IL-17 signaling pathway
KEGG
Wnt signaling pathway
KEGG
Osteoclast differentiation
Name
Explore in Pharos
Explore in Source
Human T-cell leukemia virus 1 infection
IL-17 signaling pathway
Wnt signaling pathway
Osteoclast differentiation
Gene Ontology Terms (34)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (120)
1 – 10 of 120
JUNB
Tbio
Family: TF
Novelty: 0.00841656
Score: 0.995
Data Source: STRINGDB
JUND
Tbio
Family: TF
Novelty: 0.00277701
Score: 0.994
Data Source: STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.993
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.956
Data Source: STRINGDB
NFATC1
Tbio
Family: TF
Novelty: 0.00130337
Score: 0.932
Data Source: STRINGDB
SP1
Tbio
Family: TF
Novelty: 0.0007915
Score: 0.924
Data Source: STRINGDB
USF2
Tbio
Family: TF
Novelty: 0.00516415
Score: 0.924
Data Source: STRINGDB
TXLNG
Tbio
Novelty: 0.08274423
Score: 0.921
Data Source: STRINGDB
NFATC2
Tbio
Family: TF
Novelty: 0.00312526
Score: 0.921
Data Source: STRINGDB
FOS
Tbio
Family: TF
Novelty: 0.00006103
Score: 0.913
Data Source: STRINGDB
Publication Statistics
PubMed Score  328.11

PubMed score by year
PubTator Score  306.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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