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Tbio
KCNE1
Potassium voltage-gated channel subfamily E member 1

Protein Summary
Description
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:19219384). Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337385
  • ENSP00000337255
  • ENSG00000180509
  • ENST00000399284
  • ENSP00000382225
  • ENST00000399286
  • ENSP00000382226
  • ENST00000399289
  • ENSP00000382228
  • ENST00000416357
  • ENSP00000416258
  • ENST00000432085
  • ENSP00000412498
  • ENST00000611936
  • ENSP00000478215
  • ENST00000621601
  • ENSP00000483895

Symbol
  • ISK
  • JLNS
  • LQT5
  • MinK
  • JLNS2
  • LQT2/5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
biological process
0.87
kinase
0.72
biological term
0.65
chemical
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 473.17   (req: < 5)
Gene RIFs: 137   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 473.17   (req: >= 5)
Gene RIFs: 137   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 2 - plateau phase
Reactome
Phase 3 - rapid repolarisation
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 2 - plateau phase
Phase 3 - rapid repolarisation
Protein-Protein Interactions (108)
1 – 10 of 108
SFXN3
Tdark
Novelty: 0.24
p_int: 0.995398958
p_ni: 0.004600726
p_wrong: 3.16e-7
Data Source: BioPlex
INTS7
Tdark
Novelty: 0.11980396
p_int: 0.990968852
p_ni: 0.009031148
Data Source: BioPlex
SERPINE2
Tbio
Novelty: 0.00275751
p_int: 0.987583369
p_ni: 0.01240454
p_wrong: 0.000012092
Data Source: BioPlex
MYADM
Tbio
Novelty: 0.09214874
p_int: 0.976135882
p_ni: 0.020490052
p_wrong: 0.003374066
Data Source: BioPlex
LPCAT3
Tbio
Family: Enzyme
Novelty: 0.00564842
p_int: 0.94232073
p_ni: 0.057333867
p_wrong: 0.000345403
Data Source: BioPlex
SLC7A3
Tbio
Family: Transporter
Novelty: 0.00610711
p_int: 0.937012129
p_ni: 0.016183498
p_wrong: 0.046804373
Data Source: BioPlex
FAM241A
Tdark
Novelty: 2.7184466
p_int: 0.934591054
p_ni: 0.0649023
p_wrong: 0.000506646
Data Source: BioPlex
SLC25A24
Tbio
Family: Transporter
Novelty: 0.09884975
p_int: 0.91559246
p_ni: 0.084249101
p_wrong: 0.000158439
Data Source: BioPlex
SLC25A6
Tbio
Family: Transporter
Novelty: 0.00749136
p_int: 0.900405407
p_ni: 0.099594593
Data Source: BioPlex
GPR89A
Tdark
Family: IC
Novelty: 0.13236179
p_int: 0.880874795
p_ni: 0.119120332
p_wrong: 0.000004873
Data Source: BioPlex
Publication Statistics
PubMed Score  473.17

PubMed score by year
PubTator Score  315.29

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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