Tchem KCNE1 Potassium voltage-gated channel subfamily E member 1

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / Kcne Subfamily / Potassium Voltage-gated Channel Subfamily E Member 1

Protein Summary

Description

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:19219384). Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P15382
• A5H1P2
• Q8N709
• Q91Z94

Gene Name

• KCNE1

Ensembl ID

• ENST00000337385
• ENSP00000337255
• ENSG00000180509
• ENST00000399284
• ENSP00000382225
• ENST00000399286
• ENSP00000382226
• ENST00000399289
• ENSP00000382228
• ENST00000416357
• ENSP00000416258
• ENST00000432085
• ENSP00000412498
• ENST00000611936
• ENSP00000478215
• ENST00000621601
• ENSP00000483895

Symbol

• ISK
• JLNS
• LQT5
• MinK
• JLNS2
• LQT2/5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
biological process	0.87
kinase	0.72
biological term	0.65
chemical	0.58

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 622.26   (req: < 5)

Gene RIFs: 137   (req: <= 3)

Antibodies: 243   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 622.26   (req: >= 5)

Gene RIFs: 137   (req: > 3)

Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

CHEMBL2152523

KCNE1Tchem IC

IC50 : 5.85

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
electrocardiography	EFO_0004327	1	2	88		90.1
QT interval	EFO_0004682	5	3	3	3.1	89.5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
electrocardiography	EFO_0004327	88		90.1
QT interval	EFO_0004682	3	3.1	89.5

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Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	potassium voltage-gated channel subfamily E member 1		474097
Mouse	potassium voltage-gated channel, Isk-related subfamily, member 1	MGI:96673	16509
Rat	potassium voltage-gated channel subfamily E regulatory subunit 1	RGD:2956	25471
Dog	potassium voltage-gated channel subfamily E regulatory subunit 1		487743
Horse	potassium voltage-gated channel subfamily E regulatory subunit 1		100062537

Species	Name	OMA	EggNOG	Inparanoid
Chimp	potassium voltage-gated channel subfamily E member 1
Mouse	potassium voltage-gated channel, Isk-related subfamily, member 1
Rat	potassium voltage-gated channel subfamily E regulatory subunit 1
Dog	potassium voltage-gated channel subfamily E regulatory subunit 1
Horse	potassium voltage-gated channel subfamily E regulatory subunit 1

Protein Structure (1 Structure, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

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More information can be found at RCSB PDB

AF-P15382-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (6)

Reactome (4)

KEGG (1)

WikiPathways (1)

Cardiac conduction (R-HSA-5576891)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cardiac conduction	137 targets	R-HSA-5576891
Reactome	Muscle contraction	202 targets	R-HSA-397014
Reactome	Phase 2 - plateau phase	27 targets	R-HSA-5576893
Reactome	Phase 3 - rapid repolarisation	8 targets	R-HSA-5576890

Name	Explore in Pharos	Explore in Source
Cardiac conduction	137 targets	R-HSA-5576891
Muscle contraction	202 targets	R-HSA-397014
Phase 2 - plateau phase	27 targets	R-HSA-5576893
Phase 3 - rapid repolarisation	8 targets	R-HSA-5576890

Gene Ontology Terms (28)

Functions (4)

Components (7)

Processes (17)

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GO Term	Evidence	Assigned by
delayed rectifier potassium channel activity	Inferred from Direct Assay (IDA)	UniProtKB
potassium channel regulator activity	Inferred from Direct Assay (IDA)	UniProtKB
telethonin binding	Inferred from Physical Interaction (IPI)	BHF-UCL
ion channel binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (108)

Explore Interacting Targets

1 – 10 of 108

• See Interactions on String-DB

SFXN3

Tbio

Novelty:  0.18698456

p_int:  0.995398958

p_ni:  0.004600726

p_wrong:  3.16e-7

Data Source:  BioPlex

INTS7

Tdark

Novelty:  0.04592325

p_int:  0.990968852

p_ni:  0.009031148

Data Source:  BioPlex

SERPINE2

Tbio

Novelty:  0.00246375

p_int:  0.987583369

p_ni:  0.01240454

p_wrong:  0.000012092

Data Source:  BioPlex

MYADM

Tbio

Novelty:  0.11475375

p_int:  0.976135882

p_ni:  0.020490052

p_wrong:  0.003374066

Data Source:  BioPlex

LPCAT3

Tbio

Family:  Enzyme

Novelty:  0.00485213

p_int:  0.94232073

p_ni:  0.057333867

p_wrong:  0.000345403

Data Source:  BioPlex

SLC7A3

Tbio

Family:  Transporter

Novelty:  0.00779949

p_int:  0.937012129

p_ni:  0.016183498

p_wrong:  0.046804373

Data Source:  BioPlex

FAM241A

Tdark

Novelty:  1.04041354

p_int:  0.934591054

p_ni:  0.0649023

p_wrong:  0.000506646

Data Source:  BioPlex

SLC25A24

Tbio

Family:  Transporter

Novelty:  0.06151955

p_int:  0.91559246

p_ni:  0.084249101

p_wrong:  0.000158439

Data Source:  BioPlex

SLC25A6

Tchem

Family:  Transporter

Novelty:  0.0052748

p_int:  0.900405407

p_ni:  0.099594593

Data Source:  BioPlex

GPR89A

Tbio

Family:  IC

Novelty:  0.06782776

p_int:  0.880874795

p_ni:  0.119120332

p_wrong:  0.000004873

Data Source:  BioPlex

Publication Statistics

PubMed Score  622.26

PubMed score by year

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PubTator Score  315.29

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

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3D-structure
Cell membrane
Complete proteome
Deafness
Disease mutation
Glycoprotein
Ion channel
Ion transport
Long QT syndrome
Membrane

GWAS Trait Find Similar Targets

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electrocardiography
QT interval

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
cardiovascular system phenotype
digestive/alimentary phenotype
hearing/vestibular/ear phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
nervous system phenotype