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Tchem
UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

Protein Summary
Description
Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377595
  • ENSP00000366819
  • ENSG00000118939

Symbol
  • UCH-L3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
virus perturbation
0.88
histone modification site profile
0.87
interacting protein
0.8
transcription factor binding site profile
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.34   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.34   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL1241028
chemical structure image
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Reactome
Protein ubiquitination
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Neddylation
Post-translational protein modification
Protein ubiquitination
Gene Ontology Terms (12)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (169)
1 – 10 of 169
CLPB
Tbio
Family: Enzyme
Novelty: 0.00209789
p_int: 0.996115898
p_ni: 0.003884102
Score: 0.568
Data Source: BioPlex,STRINGDB
ZMYM6
Tdark
Novelty: 0.4933879
p_int: 0.962455858
p_ni: 0.037544142
Score: 0.214
Data Source: BioPlex,STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.998
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.997
Data Source: STRINGDB
RPS27A
Tbio
Novelty: 0.00658124
Score: 0.997
Data Source: Reactome,STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.996
Data Source: Reactome,STRINGDB
NEDD8
Tbio
Novelty: 0.00305343
Score: 0.99
Data Source: Reactome,STRINGDB
SENP8
Tchem
Family: Enzyme
Novelty: 0.00774396
Score: 0.984
Data Source: STRINGDB
NAE1
Tchem
Novelty: 0.0283623
Score: 0.951
Data Source: STRINGDB
UBA3
Tbio
Novelty: 0.03962261
Score: 0.948
Data Source: STRINGDB
Publication Statistics
PubMed Score  85.34

PubMed score by year
PubTator Score  45.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer