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Tbio
ATF2
Cyclic AMP-dependent transcription factor ATF-2

Protein Summary
Description
Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264110
  • ENSP00000264110
  • ENSG00000115966
  • ENST00000345739
  • ENSP00000340576
  • ENST00000392544
  • ENSP00000376327
  • ENST00000409499
  • ENSP00000386282
  • ENST00000409635
  • ENSP00000387093
  • ENST00000409833
  • ENSP00000386526
  • ENST00000426833
  • ENSP00000407911

Symbol
  • CREB2
  • CREBP1
  • HB16
  • CREB2
  • TREB7
  • CREB-2
  • CRE-BP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
kinase
1
molecular function
1
co-expressed gene
0.99
biological process
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.03   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 2316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.03   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 2316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (126)
Activation of the AP-1 family of transcription factors (R-HSA-450341)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 44
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the AP-1 family of transcription factors
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Circadian Clock
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Activation of the AP-1 family of transcription factors
Chromatin modifying enzymes
Chromatin organization
Circadian Clock
Cytokine Signaling in Immune system
Gene Ontology Terms (43)
Items per page:
10
1 – 10 of 17
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Protein-Protein Interactions (255)
1 – 10 of 255
JUNB
Tbio
Family: TF
Novelty: 0.00841656
p_int: 1
Score: 0.988
Data Source: BioPlex,STRINGDB
CREB5
Tbio
Family: TF
Novelty: 0.03857106
p_int: 0.999999999
p_ni: 1e-9
Score: 0.972
Data Source: BioPlex,STRINGDB
FOSL2
Tbio
Family: TF
Novelty: 0.00375452
p_int: 0.999999945
p_ni: 5.5e-8
Score: 0.611
Data Source: BioPlex,STRINGDB
FOS
Tbio
Family: TF
Novelty: 0.00006103
p_int: 0.999999465
p_ni: 5.35e-7
Score: 0.986
Data Source: BioPlex,STRINGDB
ATF7
Tbio
Family: TF
Novelty: 0.01470313
p_int: 0.999998982
p_ni: 0.000001006
p_wrong: 1.2e-8
Score: 0.877
Data Source: BioPlex,STRINGDB
BATF3
Tbio
Family: TF
Novelty: 0.01554987
p_int: 0.999997207
p_ni: 0.000002793
p_wrong: 1e-9
Score: 0.682
Data Source: BioPlex,STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
p_int: 0.999971494
p_ni: 0.000025679
p_wrong: 0.000002827
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
PPP2R2D
Tbio
Family: Enzyme
Novelty: 0.0658328
p_int: 0.99995977
p_ni: 0.00004023
Data Source: BioPlex
JUND
Tbio
Family: TF
Novelty: 0.00277701
p_int: 0.999956794
p_ni: 0.00003515
p_wrong: 0.000008056
Score: 0.992
Data Source: BioPlex,STRINGDB
ARIH1
Tbio
Family: Enzyme
Novelty: 0.0258739
p_int: 0.99995585
p_ni: 0.00004415
Score: 0.548
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  220.03

PubMed score by year
PubTator Score  368.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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