Protein Summary
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative ...more
- ENST00000312293
- ENSP00000308137
- ENSG00000110195
- ENST00000393676
- ENSP00000377281
- ENST00000393679
- ENSP00000377284
- ENST00000393681
- ENSP00000377286
- FOLR
- FBP
- FOLR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.82 | ||
transcription factor perturbation | 0.8 | ||
disease perturbation | 0.79 | ||
gene perturbation | 0.77 | ||
small molecule perturbation | 0.77 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 354.83 (req: < 5)
Gene RIFs: 90 (req: <= 3)
Antibodies: 432 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 354.83 (req: >= 5)
Gene RIFs: 90 (req: > 3)
Antibodies: 432 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 22
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Approved Drugs (3)
1 – 3 of 3
Active Ligands (22)
1 – 10 of 22
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | folate receptor 1 | VGNC:11775 | 451401 | |||||
Macaque | folate receptor 1 | 718388 | ||||||
Mouse | MGI:95568 | 14275 | ||||||
Rat | RGD:71032 | 171049 | ||||||
Dog | folate receptor 1 | 609612 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | folate receptor 1 | |||||
Macaque | folate receptor 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | folate receptor 1 | |||||
Protein Structure (5 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 5
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (89)
Reactome (10)
KEGG (2)
WikiPathways (77)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 10
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | COPI-mediated anterograde transport | ||||
Reactome | COPII-mediated vesicle transport | ||||
Reactome | Cargo concentration in the ER | ||||
Reactome | ER to Golgi Anterograde Transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
COPI-mediated anterograde transport | ||||
COPII-mediated vesicle transport | ||||
Cargo concentration in the ER | ||||
ER to Golgi Anterograde Transport | ||||
Gene Ontology Terms (36)
Functions (5)
Components (16)
Processes (15)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (168)
1 – 10 of 168
ACTR10
Novelty: 0.11388846
Score: 0.926
Data Source: STRINGDB
LMAN1
Novelty: 0.00595367
Score: 0.921
Data Source: STRINGDB
SPTB
Novelty: 0.00467504
Score: 0.918
Data Source: STRINGDB
TMED10
Novelty: 0.02742083
Score: 0.913
Data Source: Reactome,STRINGDB
DCTN6
Novelty: 0.30624393
Score: 0.913
Data Source: STRINGDB
ARFGAP2
Family: Enzyme
Novelty: 0.08758647
Score: 0.91
Data Source: STRINGDB
CNIH1
Novelty: 0.0932447
Score: 0.909
Data Source: STRINGDB
CAPZA1
Novelty: 0.03448517
Score: 0.908
Data Source: STRINGDB
INS
Novelty: 0.00000499
Score: 0.908
Data Source: STRINGDB
SPTBN4
Novelty: 0.02182293
Score: 0.907
Data Source: STRINGDB
Publication Statistics
PubMed Score 354.83
PubMed score by year
PubTator Score 287.84
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword