Protein Summary
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative ...more
- ENST00000312293
- ENSP00000308137
- ENSG00000110195
- ENST00000393676
- ENSP00000377281
- ENST00000393679
- ENSP00000377284
- ENST00000393681
- ENSP00000377286
- FOLR
- FBP
- FOLR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.82 | ||
transcription factor perturbation | 0.8 | ||
disease perturbation | 0.79 | ||
gene perturbation | 0.77 | ||
small molecule perturbation | 0.77 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 231.99 (req: < 5)
Gene RIFs: 90 (req: <= 3)
Antibodies: 432 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 231.99 (req: >= 5)
Gene RIFs: 90 (req: > 3)
Antibodies: 432 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 22
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Approved Drugs (3)
1 – 3 of 3
Active Ligands (22)
1 – 10 of 22
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (89)
Reactome (10)
KEGG (2)
WikiPathways (77)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 10
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | COPI-mediated anterograde transport | ||||
Reactome | COPII-mediated vesicle transport | ||||
Reactome | Cargo concentration in the ER | ||||
Reactome | ER to Golgi Anterograde Transport | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
COPI-mediated anterograde transport | ||||
COPII-mediated vesicle transport | ||||
Cargo concentration in the ER | ||||
ER to Golgi Anterograde Transport | ||||
Gene Ontology Terms (36)
Functions (5)
Components (16)
Processes (15)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (168)
1 – 10 of 168
ACTR10
Novelty: 0.17285319
Score: 0.926
Data Source: STRINGDB
LMAN1
Novelty: 0.00340578
Score: 0.921
Data Source: STRINGDB
SPTB
Novelty: 0.0031907
Score: 0.918
Data Source: STRINGDB
TMED10
Novelty: 0.0307377
Score: 0.913
Data Source: Reactome,STRINGDB
DCTN6
Novelty: 0.93301435
Score: 0.913
Data Source: STRINGDB
ARFGAP2
Family: Enzyme
Novelty: 0.07850068
Score: 0.91
Data Source: STRINGDB
CNIH1
Novelty: 0.13636364
Score: 0.909
Data Source: STRINGDB
CAPZA1
Novelty: 0.04371834
Score: 0.908
Data Source: STRINGDB
INS
Novelty: 0.00000614
Score: 0.908
Data Source: STRINGDB
SPTBN4
Novelty: 0.02643805
Score: 0.907
Data Source: STRINGDB
Publication Statistics
PubMed Score 231.99
PubMed score by year
PubTator Score 287.84
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNT
1-70
SQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCE
70-140
QWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCI
140-210
QMWFDPAQGNPNEEVARFYAAAMSGAGPWAAWPFLLSLALMLLWLLS
210-257
MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWAAWPFLLSLALMLLWLLS
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