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Tchem
FOLR1
Folate receptor alpha

Protein Summary
Description
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312293
  • ENSP00000308137
  • ENSG00000110195
  • ENST00000393676
  • ENSP00000377281
  • ENST00000393679
  • ENSP00000377284
  • ENST00000393681
  • ENSP00000377286

Symbol
  • FOLR
  • FBP
  • FOLR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.82
transcription factor perturbation
0.8
disease perturbation
0.79
gene perturbation
0.77
small molecule perturbation
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 375.74   (req: < 5)
Gene RIFs: 90   (req: <= 3)
Antibodies: 432   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 375.74   (req: >= 5)
Gene RIFs: 90   (req: > 3)
Antibodies: 432   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 46
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (168)
ACTR10
Tbio
Novelty:  0.11388846
Score:  0.926
Data Source:  STRINGDB
LMAN1
Tbio
Novelty:  0.00595367
Score:  0.921
Data Source:  STRINGDB
SPTB
Tbio
Novelty:  0.00467504
Score:  0.918
Data Source:  STRINGDB
TMED10
Tbio
Novelty:  0.02742083
Score:  0.913
Data Source:  Reactome,STRINGDB
DCTN6
Tdark
Novelty:  0.30624393
Score:  0.913
Data Source:  STRINGDB
ARFGAP2
Tbio
Family:  Enzyme
Novelty:  0.08758647
Score:  0.91
Data Source:  STRINGDB
CNIH1
Tbio
Novelty:  0.0932447
Score:  0.909
Data Source:  STRINGDB
CAPZA1
Tbio
Novelty:  0.03448517
Score:  0.908
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.908
Data Source:  STRINGDB
SPTBN4
Tbio
Novelty:  0.02182293
Score:  0.907
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (89)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Reactome
ER to Golgi Anterograde Transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
COPII-mediated vesicle transport
Cargo concentration in the ER
ER to Golgi Anterograde Transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (36)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
66.3
calcium measurement
1
1
1
31.4
electrocardiography
1
1
1
15.8
heart rate response to recovery post exercise
1
1
1
9.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
66.3
calcium measurement
1
31.4
electrocardiography
1
15.8
heart rate response to recovery post exercise
1
9.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
folate receptor 1
VGNC:11775
451401
Macaque
folate receptor 1
718388
Mouse
MGI:95568
14275
Rat
RGD:71032
171049
Dog
folate receptor 1
609612
Species
Name
OMA
EggNOG
Inparanoid
Chimp
folate receptor 1
Macaque
folate receptor 1
Mouse
Rat
Dog
folate receptor 1
Publication Statistics
PubMed Score 375.74
PubMed score by year
PubTator Score 287.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title